{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:29:41Z","timestamp":1788636581580,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare endoscopic ultrasound\u2010guided liver biopsy (EUS\u2010LB) with percutaneous liver biopsy (P\u2010LB) in terms of histological adequacy, safety, and patient\u2010reported pain in parenchymal liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center randomized controlled trial, 80 patients were assigned to either EUS\u2010LB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941) or P\u2010LB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939). The primary endpoint was histological adequacy, defined as total specimen length (TSL)\u2009\u2265\u200915\u2009mm and \u2265\u20096 complete portal tracts (CPTs). The main secondary endpoints were the definitive histological diagnostic rate, specimen characteristics (CPTs, TSL, and longest specimen length), patient\u2010reported pain, and procedure\u2010related adverse events (AEs). EUS\u2010LB employed a 19\u2010gauge Franseen\u2010tip needle with wet suction under conscious sedation, whereas P\u2010LB used a 16\u2010gauge Tru\u2010Cut needle under local anesthesia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histological adequacy based on predefined histologic criteria was achieved more frequently with EUS\u2010LB than with P\u2010LB (70.7% vs. 10.3%; difference, 60.4%; 95% CI 43.5\u201377.3). The definitive histological diagnostic rates were similar (92.7% vs. 97.4%). The median TSL was longer with EUS\u2010LB (20.0 vs. 12.8\u2009mm), whereas \u2265\u20096 CPTs were more common with P\u2010LB (97.4% vs. 80.5%). AEs occurred in 2.4% versus 25.6%, driven in the P\u2010LB arm by procedural stress\u2013related hemodynamic responses (transient grade III hypertension); patient\u2010reported pain favored EUS\u2010LB (no pain during the procedure, 95.1% vs. 30.8%). No serious AEs or bleeding events occurred, and none required prolonged hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EUS\u2010LB met the noninferiority criterion for histologic adequacy and achieved a diagnostic performance comparable to that of P\u2010LB with lower patient\u2010reported pain. EUS\u2010LB may be a reasonable alternative when endoscopic expertise and sedation are available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70433","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T23:40:31Z","timestamp":1779061231000},"page":"2130-2137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Randomized Controlled Trial of Endoscopic Ultrasound\u2010Guided Liver Biopsy Versus Percutaneous Liver Biopsy for Obtaining Histologically Adequate Specimens"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-1299","authenticated-orcid":false,"given":"Kosuke","family":"Okuwaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-9021","authenticated-orcid":false,"given":"Masafumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-1352","authenticated-orcid":false,"given":"Haruki","family":"Uojima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-5663","authenticated-orcid":false,"given":"Hisashi","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-336X","authenticated-orcid":false,"given":"Tsutomu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Department of Comprehensive Medicine, Research and Development Center for New Medical Frontiers Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-9737","authenticated-orcid":false,"given":"Akihiro","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9212-427X","authenticated-orcid":false,"given":"Taro","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8252-2771","authenticated-orcid":false,"given":"Shuichiro","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-2736","authenticated-orcid":false,"given":"Kai","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-4787","authenticated-orcid":false,"given":"Chika","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440706"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_30_18"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.07.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.09.043"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.06.031"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391412"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.08.025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.05.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06165-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0655-7462"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06391-3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.03.023"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/eus.0000000000000010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002375"},{"key":"e_1_2_10_16_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0","author":"National Cancer Institute","year":"2017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2368-4608"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01796-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0093-CP"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324495"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00191-0"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:03:01Z","timestamp":1783011781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jgh.70433"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70433","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}