{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:53:36Z","timestamp":1785772416375,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pump\u2010based chromoendoscopy is recommended for the surveillance of dysplasia associated with inflammatory bowel disease. This study was designed to compare the efficacy of pump\u2010based pan chromoendoscopy (PCE) with white\u2010light endoscopy (WLE) for the detection of colorectal neoplasia in patients at high risk of colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This randomized controlled trial prospectively recruited 366 participants who were randomly allocated in a 1:1 ratio to the WLE group and the PCE group. Primary outcome: adenoma detection rate (ADR); secondary outcome: mean number of adenomas per procedure (MAP), sessile serrated lesion detection rate (SDR), flat adenoma detection rate (FDR), and advanced adenoma detection rate (AADR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The ADR was significantly higher with PCE (86\/167, 51.5%) versus WLE (57\/165, 34.5%; RR 1.49 [95% 1.15 to 1.93]:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The FDR and SDR were significantly higher in PCE than in WLE (50.3% vs. 32.1% RR 1.57 [95% 1.20 to 2.05]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; 10.8% vs. 2.4% RR 4.45 [95% CI 1.54 to 12.86]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that using a novel spraying technique with low\u2010concentration indigo carmine during colonoscopy achieved a significantly higher detection rate for colorectal lesions. Moreover, PCE significantly increased ADR, particularly for flat adenomas and the detection rate of sessile serrated lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT06596317<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70504","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:10:10Z","timestamp":1782202210000},"page":"2329-2337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Pan\u2010Indigo Carmine Chromoendoscopy by Water\u2010Jet Pump in the Detection of Colorectal Lesions: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"41","author":[{"given":"Huimin","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-7796","authenticated-orcid":false,"given":"Rui","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"},{"name":"Shandong Provincial Clinical Research Center for Digestive Disease  Jinan Shandong China"},{"name":"Laboratory of Translational Gastroenterology Qilu Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.068"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304880"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00390.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.260"},{"key":"e_1_2_12_9_1","first-page":"336","article-title":"The Role of Chromoendoscopy in Evaluating Colorectal Dysplasia","volume":"13","author":"Buchner A. 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