{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:53:59Z","timestamp":1785772439695,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pan\u2010intestinal capsule endoscopy (PCE) is increasingly used as a minimally invasive alternative to colonoscopy in the evaluation of mid\u2010 and lower gastrointestinal bleeding (MLGIB). However, the impact of colonic transit time (CTT) on diagnostic performance remains insufficiently characterized. This study aims to assess the concordance between PCE and colonoscopy for colorectal lesions and to determine whether CTT influences diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This post hoc analysis of a prospective single\u2010center trial included patients with suspected MLGIB who underwent PCE followed by same\u2010day colonoscopy. Only complete examinations were analyzed (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200976). CTT was evaluated using predefined thresholds (\u2264\u200960, \u2264\u200990, \u2264\u2009120, and &gt;\u2009120\u2009min). Diagnostic performance for vascular polypoid lesions and clinically significant polyps (\u2265\u20096\u2009mm; \u2265\u200910\u2009mm) was calculated using colonoscopy as the reference standard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall agreement between PCE and colonoscopy was moderate for vascular lesions (\u03ba\u2009=\u20090.56) and polypoid lesions (\u03ba\u2009=\u20090.51), substantial for polyps \u2265\u20096\u2009mm (\u03ba\u2009=\u20090.67), and near perfect for polyps \u2265\u200910\u2009mm (\u03ba\u2009=\u20090.88). Longer CTT was consistently associated with improved detection of polypoid lesions. Sensitivity for polyps \u2265\u20096\u2009mm increased from 33.3% (CTT\u2009\u2264\u200990\u2009min) to 83.3% (CTT\u2009&gt;\u200990\u2009min), with corresponding \u03ba values rising from 0.34 to 0.81. Detection of vascular lesions remained relatively stable across CTT subgroups. All \u2265\u200910\u2010mm lesions were identified in CTT\u2009&gt;\u200990\u2009min and were detected by PCE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with suspected MLGIB, PCE demonstrates good overall diagnostic performance, with excellent accuracy for clinically significant polyps. CTT is a critical determinant of diagnostic reliability, particularly for polypoid lesions. Rapid colonic transit (&lt;\u200990\u2009min) warrants cautious interpretation of negative PCE examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: NCT04782986<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70505","type":"journal-article","created":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T23:04:17Z","timestamp":1782083057000},"page":"2419-2426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concordance Between Pan\u2010Intestinal Capsule Endoscopy and Colonoscopy for the Detection and Characterization of Colonic Lesions: Post Hoc Analysis on the Impact of Colonic Transit Time"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-1844","authenticated-orcid":false,"given":"Mariana","family":"Souto","sequence":"first","affiliation":[{"name":"Gastroenterology Department Unidade Local de Sa\u00fade do Alto Ave  Guimar\u00e3es Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Unidade Local de Sa\u00fade do Alto Ave  Guimar\u00e3es Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-9067","authenticated-orcid":false,"given":"V\u00edtor\u00a0Macedo","family":"Silva","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Unidade Local de Sa\u00fade do Alto Ave  Guimar\u00e3es Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-0720","authenticated-orcid":false,"given":"Bruno","family":"Rosa","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Unidade Local de Sa\u00fade do Alto Ave  Guimar\u00e3es Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine University of Minho  Braga 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