{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:26:36Z","timestamp":1788398796716,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Management of malignant colorectal polyp has been a treatment dilemma for clinicians. This study aims to evaluate the long\u2010term survival outcome of patients with and without salvage surgery after local excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2000 to December 2022, patients with T1 malignant colorectal polyp diagnosed after local excision managed by two institutions were included for retrospective review. After propensity score matching, disease\u2010free, cancer\u2010specific, and overall survival between local excision alone (LE alone) group and local excision with salvage surgery (LE\u2009+\u2009SS) group were compared using Kaplan\u2013Meier curves and log\u2010rank test. Multivariate analysis was performed with Cox regression model to identify independent risk factors affecting disease\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010nine propensity score\u2013matched pairs were extracted from 309 patients with a mean follow\u2010up of 65.3 \n 42.6\u2009months. There was no significant difference in the 8\u2010year disease\u2010free survival (LE alone, 86.7%; LE\u2009+\u2009SS, 90.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.206), cancer\u2010specific survival (LE alone, 94.4%; LE\u2009+\u2009SS, 100%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.114) and overall survival (LE alone, 84.1%; LE\u2009+\u2009SS, 90.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.400). Piecemeal resection (HR, 7.051; 95% CI, 1.856\u201326.794;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and two or more pathological risk factors (HR, 8.552; 95% CI, 1.058\u201369.095;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) were independent risk factors for worse disease\u2010free survival in multivariate analysis. Salvage surgery and presence of single risk factor alone were not associated with disease\u2010free survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Local excision alone is non\u2010inferior to local excision followed by salvage surgery in terms of long\u2010term oncological outcome. With better risk profile assessment, local excision alone can be a safe treatment option in patients with T1 colorectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70506","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:28:38Z","timestamp":1782271718000},"page":"2427-2439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does Local Excision Without Salvage Surgery Affect the Prognostic Outcome of Patients With Malignant Colorectal Polyp? A Long\u2010Term Survival Analysis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-0197","authenticated-orcid":false,"given":"Vienna\u00a0Man\u00a0Wah","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Surgery Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-2247","authenticated-orcid":false,"given":"Simon","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Surgery Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-8756","authenticated-orcid":false,"given":"Anson\u00a0Huen\u00a0Yan","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9246-9011","authenticated-orcid":false,"given":"Sok\u00a0Fei","family":"Hon","sequence":"additional","affiliation":[{"name":"Department of Surgery Prince of Wales Hospital  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-9297","authenticated-orcid":false,"given":"Simon\u00a0Siu\u00a0Man","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Surgery The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327736"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"17","article-title":"Colorectal Malignant Polyps: A Modern Approach","volume":"35","author":"Saraiva S.","year":"2022","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2023.02.027"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.050"},{"key":"e_1_2_9_7_1","unstructured":"\u201cColon Cancer Version 2.2026 NCCN Clinical Practice Guidelines in Oncology \u201d Retrieved 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