{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:07:27Z","timestamp":1787238447068,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The incidence of ulcerative colitis (UC) has been increasing in Asia. Comprehensive data on the long\u2010term course of moderate\u2010to\u2010severe UC remain scarce. This study investigated the clinical outcomes and factors associated with a disabling disease course in Korean patients with moderate\u2010to\u2010severe UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The moderate\u2010to\u2010severe ulcerative colitis in Korea study was a prospective, multicenter, hospital\u2010based inception cohort study that enrolled patients with newly diagnosed moderate\u2010to\u2010severe UC between August 2014 and February 2017. Clinical outcomes and factors associated with a disabling disease course were evaluated over 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 353 patients included, the median follow\u2010up duration was 4.9 (interquartile range, 2.1\u20135.0) years, and 214 patients (60.6%) completed the 5\u2010year follow\u2010up. At 5\u2009years, the cumulative rates of outcomes were clinical relapses, 62.9%; proximal disease extension, 29.5%; and UC\u2010related hospitalization, 22.4%. Colectomy was required in two patients (0.6%), without mortality. A disabling disease course occurred in 171 patients (48.4%), with cumulative probabilities of 41.0%, 51.1%, and 53.9% at 12, 36, and 60\u2009months, respectively. Elevated baseline white blood cell count was independently associated with a disabling disease course (adjusted hazard ratio: 1.06; 95% confidence interval: 1.00\u20131.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Five distinct partial Mayo score\u2013based disease trajectory clusters were identified, demonstrating clear prognostic separation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While Korean patients with moderate\u2010to\u2010severe UC showed a benign structural disease course with minimal colectomy rates, approximately half experienced a disabling disease course. The identified disease trajectories provide a novel framework for risk stratification and personalized management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70508","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:31:57Z","timestamp":1782786717000},"page":"2338-2348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Five\u2010Year Outcomes and Disease Trajectories in Moderate\u2010to\u2010Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-6325","authenticated-orcid":false,"given":"Byong\u00a0Duk","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Inflammatory Bowel Disease Center Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u00a0Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Center for Crohn's and Colitis Kyung Hee University Hospital, Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u00a0Il","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u00a0Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Nowon Eulji Hospital, Eulji University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang\u2010Moon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Vincent's Hospital, The Catholic University of Korea College of Medicine  Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u00a0Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Ae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u00a0Tae","family":"Jeen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University, Anam Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u00a0Myung","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-8904","authenticated-orcid":false,"given":"Jae\u00a0Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Severance Hospital, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u00a0Noh","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngdoe","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Affairs, Johnson &amp; Johnson  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u00a0Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Medical Affairs, Johnson &amp; Johnson  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YoungJa","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical Affairs, Johnson &amp; Johnson  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-3825","authenticated-orcid":false,"given":"Chang\u00a0Kyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Center for Crohn's and Colitis Kyung Hee University Hospital, Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15389"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz081"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i9.1154"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i3.428"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319699"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2019.00005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15435"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12183"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl19107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.038"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802600961"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.3.336"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2019.00026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.08.025"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2018-000212"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4640-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf089"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2021.00104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12634"},{"issue":"9","key":"e_1_2_10_23_1","first-page":"1113","article-title":"An Intergenic Variant rs9268877 Between HLA\u2010DRA and HLA\u2010DRB Contributes to the Clinical Course and Long\u2010Term Outcome of Ulcerative Colitis","volume":"12","author":"Lee H. 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