{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:29:02Z","timestamp":1788200942178,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474378"],"award-info":[{"award-number":["82474378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to identify differentially expressed proteins (DEPs) in the gastric mucosa of patients with gastric precancerous lesions, establish a differential protein expression profile, and investigate the associated biological processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Quantitative proteomic analysis of gastric mucosal tissues from 60 patients\u2014including 20 each diagnosed with chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and low\u2010grade intraepithelial neoplasia (LGIN)\u2014was performed using data\u2010independent acquisition liquid chromatography\u2013tandem mass spectrometry (DIA LC\u2013MS\/MS). DEPs were identified using stringent statistical criteria (|log\n                      <jats:sub>2<\/jats:sub>\n                      fold change [FC]|\u2009&gt;\u20091.2, false discovery rate [FDR]\u2009&lt;\u20090.05). Subsequent bioinformatic analyses included Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, as well as receiver operating characteristic (ROC) curve assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 591 proteins were identified across the CAG, IM, and LGIN groups. Comparative analysis revealed 21 statistically significantly DEPs primarily associated with metabolic pathways, signal transduction, cytoskeletal organization, viral infection, carcinogenesis, endocytosis, and the spliceosome. Notably, Parkinson's disease protein 7 (PARK7) was consistently downregulated and exhibited differential expression across all three pathological stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study delineates characteristic protein alterations in the gastric mucosa throughout the progression of gastric precancerous lesions along the CAG\u2010IM\u2010LGIN sequence. PARK7 demonstrates high diagnostic potential and may serve as a promising biomarker for monitoring disease progression in gastric precancerous conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70512","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:49:13Z","timestamp":1782877753000},"page":"2393-2404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Chronic Atrophic Gastritis to Low\u2010Grade Intraepithelial Neoplasia: A Proteomic Study on the Sequential Progression of Gastric Precancerous Lesions"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3605-878X","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Putuo Hospital Shanghai University of Traditional Chinese Medicine  Shanghai 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