{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:23:06Z","timestamp":1792804986269,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000345103"],"award-info":[{"award-number":["RS\u20102024\u201000345103"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","award":["RS\u20102023\u201000228946"],"award-info":[{"award-number":["RS\u20102023\u201000228946"]}],"id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Many studies have reported an association between\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n infection and an increased risk of colorectal cancer (CRC); however, the impact of eradication therapy on CRC remains unclear. We compared CRC incidence and mortality in individuals who received\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n treatment with those in the general population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a population\u2010based study of 931\u2009585 participants aged \u2265\u200920\u2009years who received\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication (HPE) therapy between 2009 and 2011. We used the one\u2010sample log\u2010rank test to compare standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) for CRC.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean follow\u2010up period was 12.4\u2009\u00b1\u20091.1\u2009years. CRC incidence and mortality rates were significantly lower in\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n \u2013treated individuals than in the general population (total SIR: 0.66, 95% confidence intervals [CI] 0.64\u20130.67 and SMR: 0.51, 95% CI 0.49\u20130.54). Significant results were also observed in the 30\u201339, 40\u201349, 50\u201359, 60\u201369, and \u2265\u200970 age groups: The SIRs (95% CIs) were 0.80 (0.71\u20130.89), 0.73 (0.70\u20130.77), 0.62 (0.60\u20130.65), 0.66 (0.63\u20130.68), and 0.62 (0.59\u20130.66), respectively, and the SMRs (95% CIs) were 0.53 (0.36\u20130.76), 0.46 (0.39\u20130.54), 0.41 (0.37\u20130.46), 0.48 (0.44\u20130.53), and 0.65 (0.60\u20130.71), respectively. Similar results were observed when colon and rectal cancer were analyzed separately.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n HPE may help reduce the risk and improve the survival from CRC. Its benefits may extend beyond preventing gastric cancer to CRC prevention. Our findings support the need for aggressive\n \n H.\u2009pylori<\/jats:italic>\n <\/jats:styled-content>\n screening and eradication treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.70532","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:15:21Z","timestamp":1782911721000},"page":"2356-2364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventive Effect of\n \n Helicobacter pylori<\/i>\n <\/scp>\n Treatment on Colorectal Cancer Incidence and Mortality"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-7170","authenticated-orcid":false,"given":"Yoon\u00a0Suk","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine Seoul Republic of Korea"},{"name":"Institute for Health and Society, Hanyang University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine Seoul Republic of Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology, Hanyang University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-913X","authenticated-orcid":false,"given":"Chang\u00a0Mo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Ewha Womans University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30488-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320839"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000127"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000033177"},{"key":"e_1_2_10_7_1","first-page":"92","article-title":"Meta\u2010Analysis of the Correlation Between Helicobacter pylori Infection and the Risk of Colorectal Neoplasia","volume":"30","author":"Xu H.","year":"2024","journal-title":"Alternative Therapies in Health and 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https:\/\/kosis.kr\/eng\/."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2015.06.012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2021.044"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.5124\/jkma.2016.59.3.221"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204762"},{"key":"e_1_2_10_17_1","first-page":"203","article-title":"Epidemiology and Risk of Colorectal Cancer in Patients With a History of Helicobacter pylori Infection: A Population\u2010Based Study","volume":"36","author":"Boustany A.","year":"2023","journal-title":"Annals of 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