{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:37:18Z","timestamp":1792103838788,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hepatitis B virus (HBV), hepatitis C virus (HCV), and metabolic dysfunction\u2010associated steatotic liver disease (MASLD) are common liver diseases. Clinical characteristics and patient\u2010reported outcomes (PROs) of HBV and HCV patients with\/without superimposed MASLD were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Cross\u2010sectional study of clinical and PRO (FACIT\u2010Fatigue [FACIT\u2010F], Chronic Liver Disease Questionnaire [CLDQ], Work Productivity and Activity Impairment [WPAI] questionnaire) data from Global Liver Registry, HBV and HCV patients. MASLD was defined as Hepatic Steatosis Index (HSI)\u2009\u2265\u200936 with \u2265\u20091 cardiometabolic risk factor (overweight, type 2 diabetes, hypertension, and hyperlipidemia).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 4649 subjects, 2063 had HBV (48\u2009\u00b1\u200913\u2009years; 57% male; 11% advanced fibrosis; 49% MASLD); 2586 had HCV (56\u2009\u00b1\u200914\u2009years; 47% male; 18% advanced fibrosis; 47% MASLD). HBV with\/without MASLD were similar in age, sex, and noncardiometabolic comorbidities (all\n p<\/jats:italic>\n \u2009>\u20090.05) but those with MASLD had more advanced fibrosis (\n p<\/jats:italic>\n \u2009<\u20090.01) and significantly lower PRO scores: FACIT\u2010F Physical Well\u2010Being and Fatigue domains and all CLDQ (all\n p<\/jats:italic>\n \u2009<\u20090.01) especially Fatigue domain (6% reduction in score range). HCV patients with MASLD were younger, more frequently female (\n p<\/jats:italic>\n \u2009<\u20090.01) with similar rates of advanced fibrosis, biopsy\u2010proven cirrhosis, and noncardiometabolic comorbidities (all\n p<\/jats:italic>\n \u2009>\u20090.05). They had significantly lower scores in FACIT\u2010F Physical Well\u2010Being and all CLDQ domains (all\n p<\/jats:italic>\n \u2009<\u20090.01); the greatest impairment was in Systemic Symptoms and Worry domains (6% reduction in score range).\n <\/jats:p>\n \n MASLD was independently associated with lower CLDQ scores in multivariate analysis (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Approximately half of HBV or HCV patients had MASLD and reported significantly worse PROs, highlighting the importance of proactive metabolic assessment and management in patients with chronic viral hepatitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.70533","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:18:36Z","timestamp":1783556316000},"page":"2440-2447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Viral Hepatitis With MASLD: Implications for Clinical and Patient\u2010Reported Outcomes"],"prefix":"10.1111","volume":"41","author":[{"given":"George","family":"Papatheodoridis","sequence":"first","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"1st<\/sup> Department of Gastroenterology National\/Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Buti","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Vall d'Hebron University Hospital Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5283","authenticated-orcid":false,"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Department of Gastroenterology, School of Medicine Recep Tayyip Erdo\u011fan University Rize T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1900","authenticated-orcid":false,"given":"Ming\u2010Lung","family":"Yu","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Hepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital and Center of Metabolic Disorders and Obesity, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Kassas","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Endemic Medicine Department, Faculty of Medicine Helwan University Cairo Egypt"},{"name":"Applied Science Research Center Applied Science Private University Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3521-8523","authenticated-orcid":false,"given":"Khalid","family":"Alswat","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-2064","authenticated-orcid":false,"given":"Marlen\u00a0Ivon\u00a0Castellanos","family":"Fernandez","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"University of Medical Sciences of Havana Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-5736","authenticated-orcid":false,"given":"Yuichiro","family":"Eguchi","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Loco Medical General Institute Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Duseja","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-5554","authenticated-orcid":false,"given":"Caglayan","family":"Keklikkiran","sequence":"additional","affiliation":[{"name":"The Global NASH\/MASH and Global Liver Councils Washington DC USA"},{"name":"Department of Gastroenterology, School of Medicine Recep Tayyip 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