{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:53:47Z","timestamp":1793724827542,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colon capsule endoscopy (CCE) is an increasingly used noninvasive alternative to colonoscopy for colonic investigation. However, its widespread adoption is constrained by suboptimal completion rates (CR), inadequate bowel preparation, and a high follow\u2010up endoscopy rate (FER), collectively undermining cost\u2010effectiveness and service efficiency. Evidence on patient\u2010level predictors of these outcomes remains fragmented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. MEDLINE, Embase, CENTRAL, and PubMed Central were searched. Patient\u2010level factors associated with completion rate, bowel preparation adequacy, successful CCE, and FER were extracted. Random\u2010effects meta\u2010analyses were performed to pool unadjusted and adjusted odds ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies comprising 4374 participants met inclusion criteria. The pooled completion rate was 73% (95% CI 68%\u201378%), and pooled bowel preparation adequacy was 72% (95% CI 60%\u201381%). Chronic opioid use was consistently associated with reduced performance, demonstrating lower completion rates (unadjusted OR 0.54, 95% CI 0.40\u20130.73; adjusted OR 0.55, 95% CI 0.28\u20131.09) and poorer bowel preparation adequacy (adjusted OR 0.49, 95% CI 0.26\u20130.96). Diabetes was independently associated with inadequate bowel preparation (adjusted OR 0.40, 95% CI 0.36\u20130.45). Increasing age showed borderline statistical significance but minimal clinical impact. The pooled follow\u2010up endoscopy rate was 61% (95% CI 56%\u201367%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCE performance is strongly influenced by patient\u2010level factors, particularly chronic opioid use and diabetes. Targeted patient selection is the most immediately actionable strategy to improve efficiency, whereas individual participant data meta\u2010analyses are needed to enable robust risk stratification of CCE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70535","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:08:06Z","timestamp":1782925686000},"page":"2286-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient\u2010Level Predictors of Procedural Success in Colon Capsule Endoscopy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Ian\u00a0Io","family":"Lei","sequence":"first","affiliation":[{"name":"Institute of Precision Diagnostics &amp; Translational Medicine University Hospital of Coventry and Warwickshire  Coventry UK"},{"name":"Warwick Medical School University of Warwick  Coventry UK"},{"name":"Department of Gastroenterology Royal Berkshire Hospital  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Vuggumudi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Berkshire Hospital  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-7006","authenticated-orcid":false,"given":"Kiara","family":"Mcdonnell","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Royal Berkshire Hospital  Reading UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh\u00a0P.","family":"Arasaradnam","sequence":"additional","affiliation":[{"name":"Institute of Precision Diagnostics &amp; Translational Medicine University Hospital of Coventry and Warwickshire  Coventry UK"},{"name":"Warwick Medical School University of Warwick  Coventry UK"},{"name":"Leicester Cancer Centre University of Leicester  Leicester UK"},{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-489X","authenticated-orcid":false,"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Surgery Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1258-4819"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2025-001800"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333687"},{"key":"e_1_2_11_5_1","volume-title":"JAG Accreditation Programme: Guide to Meeting the Quality and Safety Standards","author":"JAG","year":"2021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.04.2905"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617700014"},{"key":"e_1_2_11_8_1","volume-title":"Standards of Practice for Computed Tomography Colonography (CTC)","author":"Radiologist JgftBSoGaARaRCo","year":"2021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics16010020"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2024-001500"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16771"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-02048-6"},{"key":"e_1_2_11_14_1","unstructured":"Microsoft Corporation \u201cMicrosoft Excel \u201d (2018)."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108602"},{"key":"e_1_2_11_16_1","unstructured":"G.Schwarzer \u201cmeta: General Package for Meta\u2010Analysis. 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