{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:13:26Z","timestamp":1793726006925,"version":"4.6.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Positive margins after endoscopic resection of rectal neuroendocrine tumors (NETs) do not always indicate true residual disease. We aimed to identify risk factors for remnant tumors among patients with incompletely resected rectal NETs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study across 11 tertiary hospitals. Patients who underwent salvage treatment for incompletely resected rectal NETs between January 2010 and December 2023 were retrospectively reviewed. A total of 286 patients were included, and demographic, endoscopic, and pathologic data were analyzed to identify predictors of remnant tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The remnant tumor was found in 102 (35.7%) patients. Rates were highest after cold forceps polypectomy (CFP) (63.6%), followed by cold snare polypectomy (32.1%) and conventional endoscopic mucosal resection (EMR) (31.2%). No remnant tumor was observed after modified EMR or endoscopic submucosal dissection (ESD), even in cases with positive or indeterminate margins. On multivariate analysis, CFP (odds ratio [OR], 4.50; 95% confidence interval [CI], 2.33\u20138.70) and two post\u2010resection scar features\u2014yellowish mucosa (OR, 4.36; 95% CI, 2.26\u20138.40) and mucosal protrusion (OR, 4.84; 95% CI, 2.17\u201310.79)\u2014were independent predictors of remnant tumors. The risk rose stepwise with the number of factors: 15.0% (none), 52.6% (one), 78.3% (two), and 87.5% (three) (\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Margin\u2010positive rectal NETs resected by modified EMR or ESD may be managed with surveillance. However, CFP or post\u2010resection scars showing yellowish mucosa or mucosal protrusion indicate high residual risk and warrant prompt salvage resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70549","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:58:29Z","timestamp":1783299509000},"page":"2365-2373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting Remnant Tumor After Incomplete Resection of Rectal Neuroendocrine Tumors: The KASID Multicenter Retrospective Cohort Study"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-495X","authenticated-orcid":false,"given":"Hyung\u2010Hoon","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8159","authenticated-orcid":false,"given":"Jae\u2010Gon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital, Hanyang University College of Medicine  Guri Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hyun","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seoyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University College of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-5435","authenticated-orcid":false,"given":"Hyeong\u2010Ho","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daegu Catholic University, School of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Kyo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hallym University College of Medicine  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Ju","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunmi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeyoung","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Eun","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-0050","authenticated-orcid":false,"given":"Yunho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Soonchunhyang University College of Medicine  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"157","article-title":"Current Trends of the Incidence and Pathological Diagnosis of Gastroenteropancreatic Neuroendocrine Tumors (GEP\u2010NETs) in Korea 2000\u20102009: Multicenter Study","volume":"44","author":"Gastrointestinal Pathology Study Group of Korean Society of P","year":"2000","journal-title":"Cancer Research and 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NCCN Clinical Practice Guidelines in Oncology. Version 1.2023 \u201d Published January 13 2023 accessed August 15 2025 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/neuroendocrine.pdf."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13309"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2025.03.023"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002516"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1300-1017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15102766"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02365-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03736-y"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:59:29Z","timestamp":1785769169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,5]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jgh.70549"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70549","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,5]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}