{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:53:40Z","timestamp":1785772420885,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Alterations in gut microbiota composition are closely associated with obesity and metabolic disorders.\n                      <jats:italic>Cyclocarya paliurus<\/jats:italic>\n                      polysaccharides (CCPP) have been shown to improve lipid metabolism and modulate the gut microbiota; however, mechanistic evidence remains limited and may vary depending on preparation methods. This study investigated whether a crude polysaccharide\u2010enriched\n                      <jats:italic>Cyclocarya paliurus<\/jats:italic>\n                      preparation alleviates high\u2010fat diet\u2013induced metabolic dysfunction and is associated with gut microbiota remodeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male C57BL\/6\u2009J mice were randomized into three groups: normal diet (ND), high\u2010fat diet (HFD), and HFD supplemented with CCPP for 12\u2009weeks. Serum metabolic parameters were measured; intestinal inflammatory cytokine transcripts were assessed by qRT\u2010PCR; and cecal microbiota composition was analyzed by 16S rRNA gene sequencing. Additionally, fecal microbiota transplantation (FMT) was performed by transferring microbiota from CCPP\u2010treated donors to antibiotic\u2010pretreated HFD\u2010induced recipients for 8\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CCPP attenuated HFD\u2010induced body weight gain and reduced subcutaneous and visceral adipose tissue mass. CCPP significantly improved serum total cholesterol and low\u2010density lipoprotein cholesterol (LDL\u2010C) and reduced fasting glucose. Cecal 16S rRNA gene profiling showed that CCPP reshaped the gut dysbiosis associated with a HFD and enriched microbial taxa that are commonly linked to carbohydrate fermentation. These taxa specifically include\n                      <jats:italic>Lachnospiraceae<\/jats:italic>\n                      \u2010related microbial taxa and\n                      <jats:italic>Ileibacterium<\/jats:italic>\n                      . Importantly, FMT from CCPP\u2010treated donors recapitulated these metabolic improvements, confirming that the benefits of CCPP were microbiota\u2010dependent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCPP mitigates obesity and metabolic dysfunction by remodeling the gut microbiota, particularly by enriching short\u2010chain fatty acid\u2010producing taxa. These findings highlight CCPP as a potential microbiota\u2010targeted therapeutic agent for metabolic disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70551","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:17:56Z","timestamp":1783667876000},"page":"2405-2418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>\n                      <scp>Cyclocarya paliurus<\/scp>\n                    <\/i>\n                    Polysaccharides Attenuate High\u2010Fat Diet\u2010Induced Metabolic Dysfunction via Gut Microbiota Remodeling"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8281-1578","authenticated-orcid":false,"given":"Chengyan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital Affiliated to Shanxi Medical University\/Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences  Taiyuan Shanxi China"},{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences  Guangzhou China"},{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital Affiliated to Shanxi Medical University\/Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences  Taiyuan Shanxi China"},{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"},{"name":"Department of Medical Imaging Shanxi Medical University  Taiyuan Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"},{"name":"Department of Postgraduate Education Jinzhou Medical University  Jinzhou Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Su","sequence":"additional","affiliation":[{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"},{"name":"Department of Medical Imaging Shanxi Medical University  Taiyuan Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"},{"name":"Hengyang Medical School, University of South China  Hengyang Hunan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelan","family":"Luo","sequence":"additional","affiliation":[{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"},{"name":"School of Medical Technology Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Fenyang College, Shanxi Medical University  Fenyang Shanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital Affiliated to Shanxi Medical University\/Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Hospital Affiliated to Shanxi Medical University\/Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02750-2"},{"key":"e_1_2_9_3_1","unstructured":"Organization WH \u201cNoncommunicable Diseases \u201d (2017) http:\/\/www.who.int\/mediacentre\/factsheets\/fs355\/en\/."},{"key":"e_1_2_9_4_1","unstructured":"S. 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