{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:35:26Z","timestamp":1791660926764,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Whether the efficacy of vonoprazan\u2013amoxicillin dual therapy (VADT) for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Helicobacter pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication is clinically acceptable compared with guideline\u2010recommended bismuth\u2010based quadruple therapy (BQT) remains uncertain. Prior analyses have largely relied on superiority frameworks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      PubMed, EMBASE, and CENTRAL were searched through December 23, 2025, for randomized controlled trials (RCTs) comparing VADT with BQT for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H. pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      eradication. Intention\u2010to\u2010treat and per\u2010protocol eradication were summarized through Bayesian meta\u2010analysis as absolute risk differences. Noninferiority margins were prespecified at \u221210%, \u22125%, and 0% (superiority). Adverse events (AEs) were evaluated as secondary outcomes. Evidence certainty was assessed using GRADE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen Asian RCTs (5866 participants) were included. In intention\u2010to\u2010treat analyses, VADT achieved an absolute eradication increase of +2.27% compared with BQT (95% credible interval [CrI] \u22121.34% to +5.71%). The posterior probability of noninferiority exceeded 99% for the \u221210% and \u22125% margins but declined to 90.41% at 0%. In per\u2010protocol analyses, eradication showed an absolute decrease of 0.28% (95% CrI \u22123.30% to +4.17%), with noninferiority probabilities exceeding 99% for the \u221210% and \u22125% margins, but declining to 56.43% at 0%. VADT was associated with significantly lower rates of dysgeusia, dizziness\/headache, nausea\/vomiting, and overall mild AEs. Evidence certainty was moderate for intention\u2010to\u2010treat noninferiority in Eastern populations and low or very low for all other Eastern and Western analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>VADT may be a reasonable alternative in East Asian settings where tolerability or regimen simplicity is a priority, but evidence is insufficient to support generalization to Western or non\u2010Asian populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70565","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:49:49Z","timestamp":1783759789000},"page":"2545-2556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Eradication of\n                    <scp>\n                      <i>Helicobacter pylori<\/i>\n                    <\/scp>\n                    With Vonoprazan\u2013Amoxicillin Dual Therapy as an Alternative for Bismuth\u2010Based Quadruple Therapy: A Systematic Review and Noninferiority Meta\u2010Analysis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9049-0996","authenticated-orcid":false,"given":"Pedro\u00a0Robson\u00a0Costa","family":"Passos","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM) Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valbert\u00a0Oliveira\u00a0Costa","family":"Filho","sequence":"additional","affiliation":[{"name":"N\u00facleo de Biomedicina (NUBIMED) Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-7425","authenticated-orcid":false,"given":"Mariana\u00a0Macambira","family":"Noronha","sequence":"additional","affiliation":[{"name":"N\u00facleo de Biomedicina (NUBIMED) Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa\u00a0Cortez\u00a0Braga","family":"Maia","sequence":"additional","affiliation":[{"name":"N\u00facleo de Biomedicina (NUBIMED) Universidade Federal do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-2152","authenticated-orcid":false,"given":"Guilherme\u00a0Grossi\u00a0Lopes","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Department of Gastroenterology and Hepatology Hospital da Pol\u00edcia Militar de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00070-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210794519075"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.11.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1710945"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002968"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020332"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001828"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13195762"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005457226341"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.059"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002600"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"165","article-title":"Peptic Ulcer Disease and H. pylori Infection: Common Questions and Answers","volume":"107","author":"McConaghy J. 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