{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:16:41Z","timestamp":1788319001125,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011274","name":"Guardian Angel Thrift","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The efficacy of high\u2010dose oral omeprazole in peptic ulcer bleeding after successful therapeutic hemostatic endoscopy has not been well established. This study aimed to compare the efficacy of high\u2010dose oral omeprazole versus continuous intravenous (IV) pantoprazole in rebleeding and percent time of gastric pH above 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eligible patients were randomized with 1:1 concealed allocation to 40\u2010mg oral omeprazole twice daily or IV pantoprazole 8\u2009mg\/h for 72\u2009h after index gastroscopy. Gastric pH was measured for 24\u2009h during 48\u201372\u2009h after starting the assigned medication. Rebleeding at 72\u2009h and 30\u2009days, as well as 24\u2010h gastric pH, were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 124 patients were analyzed. Seventy\u2010two\u2010hour rebleeding occurred in 1.6% (1\/61) of the oral omeprazole group and 4.8% (3\/63) of the IV pantoprazole group requiring endoscopic hemostasis (risk difference [RD] \u22123.1%, 95% CI \u221211.6% to 4.6%). Rebleeding within 30\u2009days also showed no difference between groups (3.3% vs. 4.8%, RD \u22121.5%, 95% CI \u221210.1% to 7.0%). Gastric pH monitoring was completed in 48% (29\/61) of the oral group and 41% (26\/63) of the IV group. The median percentage of gastric pH &gt;\u20096 was 56.3% (IQR 28.0%\u201392.0%) in the oral group and 27.3% (IQR 4.4%\u201377.7%) in the IV group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.064).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High\u2010dose oral omeprazole may represent a feasible alternative to continuous IV pantoprazole in terms of preventing rebleeding at 72\u2009h and 30\u2009days and maintaining gastric pH &gt;\u20096 among patients with peptic ulcer bleeding who underwent successful therapeutic hemostatic endoscopy.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Registration number: NCT04394663\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70566","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:02:52Z","timestamp":1783918972000},"page":"2656-2664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010Dose Oral Omeprazole Versus Continuous Intravenous Pantoprazole in Patients With High\u2010Risk Peptic Ulcer Bleeding: A Single\u2010Blinded Multicenter RCT"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5266-4386","authenticated-orcid":false,"given":"Kanteera","family":"Sriyudthsak","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross  Bangkok 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