{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:16:07Z","timestamp":1788318967531,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP 2033415"],"award-info":[{"award-number":["APP 2033415"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021954","name":"Tour de Cure","doi-asserted-by":"publisher","award":["RSP\u2010525\u2010FY2023"],"award-info":[{"award-number":["RSP\u2010525\u2010FY2023"]}],"id":[{"id":"10.13039\/501100021954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","award":["2012944"],"award-info":[{"award-number":["2012944"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010845","name":"Pancare Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001773","name":"University of New South Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017703","name":"Fundaci\u00f3n CeiBA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Although\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n plays a central role in gastric cancer (GC), other microorganisms involved in gastric dysbiosis may also impact carcinogenesis. We aimed to characterize gastric dysbiosis and its role in the transition from non\u2010atrophic gastritis (NAG) to gastric premalignant lesions (GPLs) in two populations from Nari\u00f1o, Colombia, with distinct GC risks: low\u2010risk Afro\u2010Colombians from Barbacoas and high\u2010risk Amerindian\u2010Mestizos from Cumbal.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Gastric biopsies from 200 individuals were analyzed using 16S rRNA gene sequencing. Microbial diversity and composition were assessed based on relevant clinical and sociodemographic characteristics.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection was more prevalent in Barbacoas (83.8%) than Cumbal (70.5%), alongside higher rates of obesity (\n p\u2009<<\/jats:italic>\n \u20090.001), alcohol intake (\n p<\/jats:italic>\n \u2009:\u20090.07), and smoking (\n p<\/jats:italic>\n \u2009:\u20090.02), but less severe OLGIM stages (\n p<\/jats:italic>\n \u2009:\u20090.04). In Barbacoas, alpha diversity remained stable, whereas in Cumbal, richness significantly increased in GPL (\n p<\/jats:italic>\n \u2009<\u20090.001). Beta diversity showed significant microbial composition differences between municipalities (\n p<\/jats:italic>\n \u2009<\u20090.001). In Barbacoas, taxa such as\n Prevotella<\/jats:italic>\n ,\n Haemophilus<\/jats:italic>\n , and\n Veillonella<\/jats:italic>\n were dominant, whereas lactic acid bacteria such as\n Streptococcus<\/jats:italic>\n were predominant in Cumbal. Barbacoas showed stable gastric microbiota composition across histological stages, whereas Cumbal exhibited enrichment of\n Gemella<\/jats:italic>\n ,\n Leptotrichia<\/jats:italic>\n , and\n Prevotella<\/jats:italic>\n in GPL.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n Streptococcus<\/jats:italic>\n \u2010driven dysbiosis in Cumbal may help identify microbial biomarkers for GC progression, particularly other oral pathobionts.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.70587","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:34:33Z","timestamp":1784702073000},"page":"2739-2750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in the Gastric Microbiotas of Neighboring Populations With Divergent Risks of Gastric Cancer"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-617X","authenticated-orcid":false,"given":"Juan\u00a0Camilo","family":"Caguazango","sequence":"first","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia"},{"name":"Centro de Enfermedades Digestivas y Nutricionales CIEDYN Pasto Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4925-4434","authenticated-orcid":false,"given":"Karla","family":"Vinasco","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9150-1910","authenticated-orcid":false,"given":"Isidora","family":"Simovic","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-6532","authenticated-orcid":false,"given":"Yomaira\u00a0Y\u00e9pez","family":"Caicedo","sequence":"additional","affiliation":[{"name":"Centro de Enfermedades Digestivas y Nutricionales CIEDYN Pasto Colombia"},{"name":"Programa de Nutricion y Dietetica Universidad Mariana Pasto Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1989-0045","authenticated-orcid":false,"given":"Marino\u00a0Coral","family":"Bedoya","sequence":"additional","affiliation":[{"name":"Centro de Enfermedades Digestivas y Nutricionales CIEDYN Pasto Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-1077","authenticated-orcid":false,"given":"Nadeem\u00a0O.","family":"Kaakoush","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-8872","authenticated-orcid":false,"given":"Natalia","family":"Casta\u00f1o\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-9-817"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506655103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34264"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmic.2020.100010"},{"key":"e_1_2_10_7_1","first-page":"334","article-title":"Gastric Cancer: The Colombian Enigma","volume":"25","author":"Correa P.","year":"2010","journal-title":"Revista Colombiana de Gastroenterolog\u00eda"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18594"},{"key":"e_1_2_10_9_1","volume-title":"An\u00e1lisis de Situaci\u00f3n en Salud del Departamento de Nari\u00f1o","author":"Instituto Departamental de Salud de Nari\u00f1o","year":"2023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.30944\/20117582.81"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01541-09"},{"key":"e_1_2_10_13_1","volume-title":"MicrobIEM: A User\u2010Friendly Tool for Quality Control and Interactive Analysis of Microbiome Data","author":"H\u00fclp\u00fcsch C.","year":"2021"},{"key":"e_1_2_10_14_1","volume-title":"Treating Bugs as Features: A Compositional Guide to the Statistical Analysis of the Microbiome\u2010Gut\u2010Brain Axis","author":"Bastiaanssen T. 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