{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:16:38Z","timestamp":1788318998072,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Zinc (Zn) deficiency occurs in 40% of patients with ulcerative colitis (UC). Although Zn\u2010dependent enzymes are involved in intestinal immune regulation, their relationships with Zn deficiency and mucosal inflammation remain unclear. This study aimed to investigate the associations among Zn\u2010dependent enzyme activities, serum Zn levels, and mucosal inflammatory cytokine mRNA expression in UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with UC who underwent colonoscopies from September 2019 to October 2020 were registered in a single\u2010center prospective observational study. Serum Zn levels, serum and mucosal heat\u2010resistant alkaline phosphatase (hrALP) activity, serum and mucosal ecto\u20105\u2032\u2010nucleotidase (NT5E)\/CD73 activity, and mucosal inflammatory cytokine mRNA expression were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010nine patients with UC were enrolled. Serum Zn levels were lower in the nonclinical remission group and the non\u2010endoscopic remission group. Tissue hrALP activity was higher and tissue NT5E\/CD73 activity tended to be higher in Zn\u2010deficient patients. Tissue hrALP was positively correlated with the Matts histological score, whereas tissue NT5E\/CD73 activity showed a positive trend. Serum Zn levels were inversely correlated with tissue hrALP activity. Tissue hrALP and NT5E\/CD73 activities were positively correlated with several mucosal inflammatory cytokines, whereas serum enzyme activities showed no significant correlations with inflammatory cytokine expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased mucosal Zn\u2010dependent enzyme activities were associated with histological inflammation, Zn deficiency, and mucosal inflammatory cytokine expression in UC. These findings suggest that mucosal Zn\u2010dependent enzyme activity may reflect local inflammatory status and altered Zn homeostasis in UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70588","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:48:56Z","timestamp":1784285336000},"page":"2751-2760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Zinc\u2010Dependent Enzymes on Zinc Deficiency and Inflammatory Response in Ulcerative Colitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7738-3578","authenticated-orcid":false,"given":"Yuki","family":"Murakami","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Asahikawa Medical University  Asahikawa 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