{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:34:00Z","timestamp":1793025240540,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) is a chronic, immune\u2010mediated disease in which elimination diets represent an effective therapeutic option. Although six\u2010food elimination diets (6\u2010FED) achieve high remission rates, their complexity often compromises adherence. Dairy\u2010free diet (DFD) has emerged as a simpler alternative, yet evidence in adult populations remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the clinical, endoscopic, and histological outcomes of a 12\u2010week DFD in adult patients with EoE and to explore potential predictors of histological remission and dietary adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, multicenter, open label, single\u2010arm interventional study across five Italian referral centers, enrolling 31 adults with active EoE. Participants followed a 12\u2010week DFD, after which clinical symptoms (EEsAI), disease severity (I\u2010SEE), endoscopic findings (EREFS), quality of life (EoE\u2010QOL\u2010A), and adherence (VAS scale) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight patients completed the 12\u2010week protocol. Histological remission was achieved in 53.6% of patients (intention\u2010to\u2010treat: 48.4%); among these, 86.7% also reached clinical remission. The median EEsAI improved from 35 to 18.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and the median I\u2010SEE score from 6.5 to 4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Quality of life improved (median EoE\u2010QoL\u2010A from 36.5 to 52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and adherence was high (median VAS 8 [IQR 7\u20139.5]). Predictors of lower histological response included previous esophageal dilations and higher baseline exudate and eosinophil counts. Male sex and higher BMI predicted lower adherence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this exploratory multicenter prospective study, DFD induced histological remission in more than half of patients and clinically meaningful improvements in symptoms, disease severity, endoscopy, and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70590","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:46:16Z","timestamp":1785509176000},"page":"2675-2684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of a Dairy\u2010Free Diet in Adult Patients With Eosinophilic Esophagitis: A Pilot Prospective Multicenter Study"],"prefix":"10.1111","volume":"41","author":[{"given":"Beatrice","family":"Marinoni","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Aldinio","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Organ Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6128-1874","authenticated-orcid":false,"given":"Federica","family":"Mascaretti","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Penagini","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology and Organ Transplantation University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Marabotto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pasta","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Formisano","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5301","authenticated-orcid":false,"given":"Pierfrancesco","family":"Visaggi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1060","authenticated-orcid":false,"given":"Nicola","family":"Debortoli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Guarciariello","sequence":"additional","affiliation":[{"name":"U.O.S.D. 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