{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:10:31Z","timestamp":1790287831268,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504001"],"award-info":[{"award-number":["2022YFC2504001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504006"],"award-info":[{"award-number":["2022YFC2504006"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570633"],"award-info":[{"award-number":["82570633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy of the colloidal gold immunochromatographic assay\u2010based fecal calprotectin (CGICA\u2010FC) for detecting colonoscopic abnormalities in patients with chronic diarrhea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective diagnostic study across 15 centers in China. All patients with chronic diarrhea underwent colonoscopy. We quantitatively measured FC concentrations before bowel preparation and assessed diagnostic performance using ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 556 patients with chronic diarrhea and 152 nondiarrhea controls were enrolled. FC levels were significantly higher in patients with Crohn's disease, followed by ulcerative colitis and other inflammation, compared to those with high\u2010risk adenomas, minor benign findings, normal mucosa, or nondiarrhea controls. For screening colonoscopic abnormalities from nonsignificant findings (normal mucosa &amp; minor benign findings), the optimal cutoff was 93.8\u2009\u03bcg\/g (AUC\u2009=\u20090.830). FC demonstrated higher discriminatory power for colorectal inflammation (including IBD and other inflammation) with a cutoff of 118.4\u2009\u03bcg\/g (AUC\u2009=\u20090.896) and was most accurate for identifying IBD specifically (cutoff 157.0\u2009\u03bcg\/g, AUC\u2009=\u20090.929). However, its accuracy for detecting high\u2010risk adenomas was limited (AUC\u2009=\u20090.587). FC showed high negative predictive value (NPV = 0.898\u20130.973) based on the prescreening patients with a low prior probability of abnormalities. Multivariate analysis identified colorectal inflammation and alcohol consumption as independent positive correlates with FC levels, while BMI showed a negative association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CGICA\u2010FC test is an accurate noninvasive tool for triaging patients with chronic diarrhea, with high diagnostic accuracy for identifying colorectal inflammation. Owing to its high NPV, it holds promise for reducing unnecessary colonoscopies in prescreening patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Chinese Clinical Trial Registry<\/jats:title>\n                    <jats:p>ChiCTR2300070117.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70591","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:32:47Z","timestamp":1784593967000},"page":"2665-2674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Diagnostic Accuracy of Fecal Calprotectin for Colonoscopic Abnormalities in Patients With Chronic Diarrhea"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9992-6230","authenticated-orcid":false,"given":"Xinghuang","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hubei Provincial Hospital of Traditional Chinese Medicine  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-1994","authenticated-orcid":false,"given":"Xia","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Wuhan Third Hospital (Tongren Hospital of Wuhan University)  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology the First Affiliated Hospital of Henan Medical University, Xinxiang Key Laboratory of Precision Diagnosis and Treatment for Inflammatory Bowel Disease  Xinxiang 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Gastroenterology The Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangming","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Puren Hospital of Wuhan University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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