{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:16:48Z","timestamp":1788319008195,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC114\u20102314\u2010B\u2010037\u2010038"],"award-info":[{"award-number":["NSTC114\u20102314\u2010B\u2010037\u2010038"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NSYSU\u2010KMU\u2010114\u2010P09"],"award-info":[{"award-number":["NSYSU\u2010KMU\u2010114\u2010P09"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["NHRIKMU\u2010113\u2010I002"],"award-info":[{"award-number":["NHRIKMU\u2010113\u2010I002"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMUH114\u20104R09"],"award-info":[{"award-number":["KMUH114\u20104R09"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019756","name":"Kaohsiung Municipal Siaogang Hospital","doi-asserted-by":"publisher","award":["KMHKS113\u201009"],"award-info":[{"award-number":["KMHKS113\u201009"]}],"id":[{"id":"10.13039\/100019756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019756","name":"Kaohsiung Municipal Siaogang Hospital","doi-asserted-by":"publisher","award":["KMHKS113\u201003"],"award-info":[{"award-number":["KMHKS113\u201003"]}],"id":[{"id":"10.13039\/100019756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019756","name":"Kaohsiung Municipal Siaogang Hospital","doi-asserted-by":"publisher","award":["KMHKS113\u201005"],"award-info":[{"award-number":["KMHKS113\u201005"]}],"id":[{"id":"10.13039\/100019756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>ADH1B genetic variants have recently emerged as a novel genetic determinant of metabolic dysfunction\u2010associated steatotic liver disease (MASLD); however, their clinical significance in Asian populations is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used multivariable logistic regression to evaluate the association between ADH1B genetic variants and MASLD risk and mediation analysis to quantify the direct effects of ADH1B polymorphisms and the indirect effects mediated by central obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AA genotype was associated with lower waist circumference (81.9\u2009\u00b1\u200911.0\u2009cm) and higher liver computed tomography (CT) attenuation (58.7\u2009\u00b1\u20099.3\u2009HU) compared with the AG (84.1\u2009\u00b1\u200911.1\u2009cm; 56.9\u2009\u00b1\u20099.4\u2009HU) and GG (84.7\u2009\u00b1\u20099.6\u2009cm; 54.0\u2009\u00b1\u20099.8\u2009HU) genotypes. Compared with the AA genotype, the GG and AG genotypes were associated with a higher MASLD risk by both ultrasonography (GG: OR\u2009=\u20093.97, 95% CI: 1.68\u20139.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002; AG: OR\u2009=\u20091.97, 95% CI: 1.16\u20133.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and CT criteria (GG: OR\u2009=\u20093.98, 95% CI: 1.75\u20139.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; AG: OR\u2009=\u20092.33, 95% CI: 1.47\u20133.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Waist circumference mediated 17.4% and 30.2% of the associations between the ADH1B dominant genotype and MASLD by CT liver\u2010to\u2010spleen attenuation ratio &lt;\u20091.0 and ultrasonography. Waist circumference accounted for 39.7% of the association between the ADH1B dominant genotype and hepatic steatosis assessed by liver CT attenuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADH1B variants were associated with MASLD, and mediation analysis demonstrated a statistical mediation pattern involving waist circumference that was consistent with a hypothesized adipose\u2013liver pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70632","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:57:11Z","timestamp":1785830231000},"page":"2893-2902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between ADH1B rs1229984 Genetic Polymorphism and Hepatic Steatosis Assessed by CT Attenuation: A Mediation Analysis of Central Obesity in MASLD"],"prefix":"10.1111","volume":"41","author":[{"given":"Chih\u2010Wen","family":"Wang","sequence":"first","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Ph.D. Program in Environmental and Occupational Medicine, College of Medicine Kaohsiung Medical University and National Health Research Institutes  Kaohsiung Taiwan"},{"name":"Research Center for Precision Environmental Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-7618","authenticated-orcid":false,"given":"Ming\u2010Lun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung 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Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai\u2010Jen","family":"Hou","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine and Hepatitis Research Center, College of Medicine and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University  Kaohsiung 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