{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:27Z","timestamp":1792003167538,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Upadacitinib, a selective Janus kinase 1 inhibitor, is approved to treat moderately to severely active ulcerative colitis (UC). This post hoc subanalysis evaluated the efficacy, safety, and pharmacokinetics of upadacitinib in patients in East Asia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>U\u2010ACHIEVE (UC1; NCT02819635) and U\u2010ACCOMPLISH (UC2; NCT03653026) were Phase 3, multicenter, randomized, double\u2010blind, induction studies evaluating upadacitinib 45\u2009mg or placebo daily in adults with moderately to severely active UC. Clinical responders to 8\u2009weeks of upadacitinib induction were eligible to receive upadacitinib 15\u2009mg, upadacitinib 30\u2009mg, or placebo daily in the 52\u2010week U\u2010ACHIEVE maintenance study (UC3; NCT02819635). Efficacy outcomes, safety, and pharmacokinetics were evaluated among East Asian patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A higher proportion of East Asian patients achieved clinical remission with upadacitinib than placebo at induction Week 8 (UC1:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009127, 31.4% vs. 7.3%; UC2:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009114, 31.2% vs. 2.7%) and maintenance Week 52 (UC3:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009184, upadacitinib 15\u2009mg, 52.4%; upadacitinib 30\u2009mg, 53.8%; placebo, 10.7%). Rates of endoscopic outcomes were higher with upadacitinib than with placebo across studies. No new safety signals were identified. Herpes zoster occurrences were low (UC1 and UC2: upadacitinib 45\u2009mg, two events [in one patient]; placebo, zero events; UC3: upadacitinib 15\u2009mg, five events; upadacitinib 30\u2009mg, eight events; placebo, zero events). Pharmacokinetics and trends in the relationship between upadacitinib exposure and efficacy were consistent in the East Asian and global populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Upadacitinib was generally well tolerated and effective for treating moderately to severely active UC in patients in East Asia, with a favorable benefit\u2013risk profile consistent with the global population.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02819635, NCT03653026\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70634","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:08:50Z","timestamp":1787123330000},"page":"2709-2720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy, Safety, and Pharmacokinetics of Upadacitinib Among Patients in East Asia With Moderately to Severely Active Ulcerative Colitis: A Post Hoc Subanalysis of Randomized Phase 3 Studies"],"prefix":"10.1111","volume":"41","author":[{"given":"Shu\u00a0Chen","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-6586","authenticated-orcid":false,"given":"Hiroshi","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong\u00a0Duk","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-2047","authenticated-orcid":false,"given":"Kang","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and College of Medicine  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Jinshan Branch  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Eccleston","sequence":"additional","affiliation":[{"name":"AbbVie Inc.  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