{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:20:09Z","timestamp":1792174809438,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000455210"],"award-info":[{"award-number":["RS\u20102024\u201000455210"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2013associated steatotic liver disease (MASLD) is increasingly prevalent among aging populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We evaluated hepatocellular carcinoma (HCC) risk across MASLD spectrum in this population and developed a nomogram to guide optimized surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a nationwide South Korean database, we identified participants aged \u2265\u200975\u2009years undergoing health screening between 2012 and 2015. Steatotic liver disease (SLD) was classified as MASLD, MetALD (MASLD with increased alcohol intake), or alcohol\u2010associated liver disease (ALD). Competing\u2010risk regression for HCC risk was used to estimate adjusted subdistribution hazard ratios (a\u2010sHRs) by SLD subtype, using Fine\u2013Gray models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1\u2009088\u2009314 participants, 34.3% had SLD (351\u2009583 MASLD; 11\u2009586 MetALD; 9619 ALD). The overall 5\u2010year HCC incidence in the SLD group (0.769%) was higher compared with the non\u2010SLD group (0.334%). It increased stepwise from MASLD (0.687%) to MetALD (1.856%) and ALD (2.443%): a\u2010sHRs of 1.93, 2.99, and 4.35, respectively. Stratified analyses consistently demonstrated the same pattern. A nomogram incorporating age, sex, smoking, diabetes, statin use, SLD subtype, gamma\u2010glutamyl transferase, body mass index, liver cirrhosis, and aspartate transaminase\/alanine transaminase ratio was developed, with good discriminative ability. Scores of &lt;\u2009103 (87.7% of participants) corresponded to an annual HCC risk of &lt;\u20090.2%, suggesting exemption from HCC screening, whereas scores of &gt;\u2009171 (0.14%) corresponded to an annual risk of &gt;\u20091%, indicating the need for continuous screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elderly individuals with MASLD spectrum exhibit a significant HCC risk, with higher risk in MetALD and ALD groups. Given the very small proportion who require HCC screening, our nomogram serves as a practical tool for community\u2010based risk stratification and optimized surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70635","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:12:12Z","timestamp":1785831132000},"page":"2913-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of HCC in Elderly Patients With MASLD: Proposal of an Effective Surveillance Strategy"],"prefix":"10.1111","volume":"41","author":[{"given":"Young\u00a0Eun","family":"Chon","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CHA Bundang Medical Center CHA University  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and 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