{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:26:40Z","timestamp":1791923200799,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Mitochondrial dysfunction in macrophages drives pro\u2010inflammatory M1 polarization in ulcerative colitis (UC). We developed a colon\u2010targeted, mitochondria\u2010directed nanoplatform (KSF@SS31@S100Ns) to restore mitochondrial fitness and alleviate UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Kaempferol\u2010loaded silk fibroin (SF) nanoparticles were conjugated with SS\u201031 peptide and coated with pH\u2010sensitive Eudragit S100. Physicochemical properties, release profile, and uptake were characterized. Mitochondrial function, macrophage polarization, and SIRT3\/FOXO3a signaling were assessed in LPS\u2010stimulated RAW264.7 cells. Efficacy and mechanisms were evaluated in a DSS\u2010induced colitis mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nanoparticles showed uniform size (~307\u2009nm), high stability, and pH\u2010dependent release. SS\u201031 enhanced macrophage uptake and mitochondrial localization. In\u00a0vitro, KSF@SS31Ns restored mitochondrial membrane potential and ATP, reduced ROS, promoted mitophagy, and shifted macrophages toward the M2 phenotype via SIRT3\/FOXO3a activation. In\u00a0vivo, oral KSF@SS31@S100Ns accumulated in inflamed colons, reduced disease severity, suppressed pro\u2010inflammatory cytokines, elevated IL\u201010, restored tight\u2010junction proteins, and increased M2 macrophages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KSF@SS31@S100Ns effectively treats experimental colitis by restoring mitochondrial homeostasis, reprogramming macrophage polarization, and repairing the intestinal barrier, offering a translational nanotherapeutic strategy for UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70668","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:03:42Z","timestamp":1787634222000},"page":"3150-3167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Colon\u2010 and Mitochondria\u2010Targeted Nanoparticles Alleviate Ulcerative Colitis by Reeducating Macrophage Polarization via SIRT3\/FOXO3a\u2010Mediated Mitochondrial Restoration"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6200-5475","authenticated-orcid":false,"given":"Ruya","family":"Mei","sequence":"first","affiliation":[{"name":"Graduate School Henan Medical University (formerly known as Xinxiang Medical University)  Xinxiang Henan People's Republic of China"},{"name":"Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health Sciences, Zhoupu Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health Sciences, Zhoupu Hospital  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Li","sequence":"additional","affiliation":[{"name":"Zhoupu Hospital, Shanghai University of Medicine and Health Sciences  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[{"name":"Graduate School Guizhou Medical University  Guiyang Guizhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School Shanghai University of Traditional Chinese Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Postgraduate School University of Shanghai for Science and Technology  Shanghai People's Republic of 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