{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:02:55Z","timestamp":1790848975434,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome with constipation (IBS\u2010C) and diarrhea (IBS\u2010D) exhibit highly divergent clinical manifestations. This study aims to investigate the correlation between IBS\u2010C and IBS\u2010D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants provided fecal samples and completed IBS\u2010SSS, IBS\u2010QOL, and GSRS. Fecal bacterial composition was analyzed via custom V4\u2010region 16S rRNA amplicon sequencing on the Illumina NovaSeq 6000 platform, while bile acids were quantified using liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Patients with IBS\u2010D reported significantly higher frequency and severity of diarrhea and abdominal pain. Conversely, IBS\u2010C patients experienced more severe bloating and constipation than IBS\u2010D patients. Compared to HCs, total bile acids, primary bile acids, secondary bile acids, conjugated bile acids, and unconjugated bile acids were elevated in IBS\u2010D but reduced in IBS\u2010C. The gut microbiota composition of both IBS\u2010D and IBS\u2010C patients differed significantly from that of HCs. Differential species in the IBS\u2010D group were primarily associated with Prevotella and Ruminococcaceae, those in the IBS\u2010C group were mainly concentrated in Bacteroides and Clostridium, and differential species in the HCs group were primarily found in Ruminococcus. Abundances of Clostridiaceae and Bacteroides correlated negatively with plasma chenodeoxycholic acid and cholic acid, respectively, while Clostridium correlated negatively with ursodeoxycholic acid (UDCA). Ruminococcus correlated positively with isodeoxycholic acid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alterations in the bile acid\u2013gut microbiota axis are closely related to the distinct clinical presentations of IBS\u2010C and IBS\u2010D. IBS\u2010D is characterized by a decreased abundance of Ruminococcus and Clostridium, alongside increased bile acid secretion and reduced reabsorption, which primarily contribute to the observed differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70669","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:36:33Z","timestamp":1787099793000},"page":"3168-3179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in the Plasma Bile Acid\u2010Gut Microbiota Axis Between IBS\u2010D and IBS\u2010C"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-828X","authenticated-orcid":false,"given":"Yao","family":"Chengjiao","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, West China School of Medicine Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital  Chengdu China"},{"name":"Department of Geriatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"SCATCM Key Laboratory of Digital Traditional Chinese Medicine for Prevention and Treatment of Major Chronic Diseases Sichuan University affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Zerui","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, West China School of Medicine Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital  Chengdu China"},{"name":"Department of Geriatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"},{"name":"SCATCM Key Laboratory of Digital Traditional Chinese Medicine for Prevention and Treatment of Major Chronic Diseases Sichuan University affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Mengjun","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liming","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Affiliated Hospital of North Sichuan Medical College  Nanchong 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