{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:09:05Z","timestamp":1790035745142,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Over four decades, translational hepatology has evolved from empirical observations into an evidence\u2010driven discipline. This review synthesizes key bedside discoveries, mechanistic studies, prospective cohorts, cross\u2010regional health\u2010economic evaluations, and landmark randomized controlled trials (RCTs) by our team that have helped to reshape regulatory drug approvals, Boxed Warnings, and international practice guidelines across APASL, AASLD, and EASL. First, clinical trials established the biphasic model and risk predictors of immunosuppression\u2010induced hepatitis B virus (HBV) reactivation, proving that pre\u2010emptive nucleos(t)ide analogue (NUC) prophylaxis prevents liver failure and antineoplastic disruptions. Second, multinational Phase III registration trials of finite 48\u2010week pegylated interferon alfa\u20102a (Peg\u2010IFN \u03b1\u20102a) in chronic hepatitis B (CHB)\u2014combined with intrahepatic cccDNA kinetics, adoptive immunity transfer, and 30\u2010year Asia\u2010Pacific Markov health\u2010economic modeling\u2014established response\u2010guided rules and validated finite Peg\u2010IFN switch\/add\u2010on strategies as clinically dominant and cost\u2010effective. Third, prospective cohorts uncovered direct\u2010acting antiviral (DAA)\u2013induced HBV reactivation during HCV clearance, establishing mandatory regulatory Boxed Warnings and pre\u2010DAA screening. Fourth, the Phase III HIMALAYA study and pooled Greater China (Mainland China, Hong Kong, Taiwan) cohorts validated the STRIDE regimen (single\u2010dose tremelimumab plus regular durvalumab) as frontline dual immunotherapy for unresectable hepatocellular carcinoma (uHCC), establishing marked survival benefit in HBV\u2010predominant populations (median OS 25.26 vs. 14.09\u2009months) alongside a vascular endothelial growth factor (VEGF)\u2013free standard for cirrhotic portal hypertension within APASL guidelines. Finally, translational insights across metabolic dysfunction, COVID\u201019, ACLF, artificial intelligence (AI), and functional cure frameworks inform the APASL 2026 \u201ctreat\u2010all\u201d CHB paradigm.<\/jats:p>","DOI":"10.1111\/jgh.70742","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:52:16Z","timestamp":1790034736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Translational Hepatology From Bedside to Global Policy: How Robust Clinical and Translational Research Reshapes Global Practice Guidelines and Patient Outcomes"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8928-3769","authenticated-orcid":false,"given":"George","family":"Lau","sequence":"first","affiliation":[{"name":"Humanity and Health Clinical Trial Center Humanity and Health Medical Group  Hong Kong SAR China"},{"name":"Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_12_2_1","article-title":"Reshaping Modern Hepatology: Translational Paradigms in Viral Kinetics, Immunosuppressive Reactivation, and Hepatocellular Carcinoma Immunotherapy","author":"Lau G.","year":"2026","journal-title":"Invited State\u2010of\u2010the\u2010Art Review. 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