{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:26:22Z","timestamp":1793762782787,"version":"4.6.1"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is a common disorder of gut\u2013brain interaction characterized by recurrent abdominal pain and altered bowel habits, with substantial effects on quality of life and healthcare utilization. Melatonin has been proposed as a potential adjunctive therapy because of its effects on visceral sensitivity, gastrointestinal motility, and gut\u2013brain signaling. We conducted an updated systematic review and meta\u2010analysis of randomized placebo\u2010controlled trials evaluating melatonin supplementation in adults with IBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Cochrane CENTRAL, Scopus, and Embase were searched from inception to April 13, 2026. Randomized, double\u2010blind, placebo\u2010controlled trials evaluating oral or sublingual melatonin in adults with IBS were included. Parallel\u2010group trials were quantitatively synthesized, while crossover trials were narratively summarized when outcome reporting was unsuitable for pooling. Risk of bias was assessed using RoB 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven randomized trials involving 391 participants were included; four contributed to quantitative synthesis and three were narratively reviewed. Melatonin significantly reduced moderate\u2010to\u2010severe IBS symptoms versus placebo (RR = 0.52, 95% CI = 0.39\u20130.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), improved pain frequency (SMD = 0.59, 95% CI = 0.27\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0003) and improved frequency of defecation (SMD = 0.42, 95% CI = 0.12\u20130.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0056). No significant differences were observed for overall quality of life or global sleep quality. Abdominal distension and abdominal pain intensity numerically favored melatonin without reaching statistical significance. Reported adverse effects were mild and infrequent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Melatonin may improve overall IBS symptom severity, pain\u2010related outcomes, and bowel habit measures, with an acceptable short\u2010term safety profile. Larger, high\u2010quality trials are needed to confirm long\u2010term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70743","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:16:45Z","timestamp":1790079405000},"page":"3333-3347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin Supplementation in the Management of Irritable Bowel Syndrome: An Updated Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Ghadeer\u00a0Ahmad","family":"Mahdi","sequence":"first","affiliation":[{"name":"Kuwait Institute for Medical Specializations  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-3471","authenticated-orcid":false,"given":"Noor","family":"Abotaiban","sequence":"additional","affiliation":[{"name":"Kuwaiti Board of Internal Medicine Kuwait Institute for Medical Specializations  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5802-2291","authenticated-orcid":false,"given":"Ahmed\u00a0Farid","family":"Gadelmawla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Menoufia University  Menoufia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6595-3500","authenticated-orcid":false,"given":"Mohammed","family":"Alfartaj","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7105-8324","authenticated-orcid":false,"given":"Saud\u00a0M.","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Kuwait Institute for Medical Specializations  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3872-6648","authenticated-orcid":false,"given":"Faisal\u00a0E.","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Kuwait Institute for Medical Specializations  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadigah\u00a0M.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8170-8429","authenticated-orcid":false,"given":"Amal\u00a0A.","family":"Alsubaiei","sequence":"additional","affiliation":[{"name":"Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2337-6588","authenticated-orcid":false,"given":"Abdullah\u00a0M.","family":"Alharran","sequence":"additional","affiliation":[{"name":"College of Medicine and Medical Sciences Arabian Gulf University  Manama Kingdom of 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