{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:07:39Z","timestamp":1790060859042,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Around 10% of patients with inflammatory bowel disease do not fulfill the diagnostic criteria for Crohn's disease (CD) or ulcerative colitis (UC). These cases are labelled as inflammatory bowel disease unclassified (IBDU). The aim of the study was to compare therapeutic requirements in patients with IBDU and UC and to identify predictive factors of reclassification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter retrospective cohort study based on the ENEIDA registry. Patients diagnosed with IBDU or indeterminate colitis between January 2010 and December 2016 were included. All cases were matched by sex, age at diagnosis, and disease extent with at least two UC patients from the same hospital. The Kaplan\u2013Meier method was performed to assess diagnostic changes during follow\u2010up. Fine\u2013Gray competing\u2010risks regression analysis identified predictive factors of reclassification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred and nine IBDU patients and 465 UC patients were included. After a median follow\u2010up of 90\u2009months, no significant differences were observed in the use of immunomodulator (37.3% vs. 37%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.934) and advanced therapies (29.2% vs. 23.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.143) between IBDU and UC. No statistical differences were found in the surgical rates (5.7% vs. 4.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.579). Overall, 59 IBDU patients (28.2%) were reclassified (30 UC and 29 CD). Baseline extensive colitis was associated with a lower probability of subsequent reclassification to UC (SHR: 0.33; 95% CI: 0.12\u20130.91). No independent predictive factors for reclassification to CD were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapeutic management of IBDU and UC patients tended to be similar. Two\u2010thirds of patients remained classified as IBDU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70745","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:38:26Z","timestamp":1790059106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and Reclassification Patterns in Inflammatory Bowel Disease Unclassified: A Multicenter Study Matched With Ulcerative Colitis From Spanish ENEIDA Registry"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-3766","authenticated-orcid":false,"given":"M.","family":"Gonz\u00e1lez\u2010Viv\u00f3","sequence":"first","affiliation":[{"name":"Hospital de Viladecans  Viladecans Spain"},{"name":"Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Castro Senosiain","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n IDIVAL Hospital Universitario Marqu\u00e9s de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-1929","authenticated-orcid":false,"given":"I.","family":"P\u00e9rez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria del Principado de Asturias (ISPA) Hospital Universitario Central de Asturias  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-3921","authenticated-orcid":false,"given":"J.","family":"Barrio","sequence":"additional","affiliation":[{"name":"Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL) Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-6297","authenticated-orcid":false,"given":"P.","family":"Vega Villaamil","sequence":"additional","affiliation":[{"name":"Complexo Hospitalario Universitario de Ourense  Ourense Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-6730","authenticated-orcid":false,"given":"B.","family":"Caballol Oliva","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pedrera Roman","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Jorge  Huesca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-2638","authenticated-orcid":false,"given":"M.","family":"Piqueras Cano","sequence":"additional","affiliation":[{"name":"Consorci Sanitari de Terrassa  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-5510","authenticated-orcid":false,"given":"F.","family":"Rodr\u00edguez Moranta","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge Hospitalet de Llobregat  L'Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-7581","authenticated-orcid":false,"given":"M.","family":"Iborra","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Research Group, Health Research Institute La Fe (IIS La Fe). IBD Unit, Gastroenterology Department La Fe University and Polytechnic Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9638","authenticated-orcid":false,"given":"M. J.","family":"Casanova","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Hospital Universitario de La Princesa, Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"J. P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Hospital Universitario de La Princesa, Universidad Aut\u00f3noma de Madrid (UAM), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-2831","authenticated-orcid":false,"given":"C.","family":"Tardillo Marin","sequence":"additional","affiliation":[{"name":"Hospital Universitario Nuestra Se\u00f1ora de Candelaria  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-1742","authenticated-orcid":false,"given":"L.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Canarias  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-1884","authenticated-orcid":false,"given":"M.","family":"Urpi\u2010Ferreruela","sequence":"additional","affiliation":[{"name":"Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0709-2932","authenticated-orcid":false,"given":"R. H.","family":"Lorente Poyatos","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Ciudad Real  Ciudad Real Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-1477","authenticated-orcid":false,"given":"M.","family":"Barreiro\u2010de Acosta","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Galega de Investigaci\u00f3n Sanitaria (IDIS) Hospital Cl\u00ednico Universitario de Santiago  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-831X","authenticated-orcid":false,"given":"O.","family":"Belen Galipienso","sequence":"additional","affiliation":[{"name":"ISABIAL Hospital General Universitario Dr Balmis de Alicante  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-9968","authenticated-orcid":false,"given":"L.","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Instituto Biodonostia Universidad del Pa\u00eds Vasco (UPV\/EHU), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-8868","authenticated-orcid":false,"given":"Y.","family":"Zabana","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Hospital Universitari Mutua Terrassa  Terrassa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0239-8193","authenticated-orcid":false,"given":"F.","family":"Murciano","sequence":"additional","affiliation":[{"name":"Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-7196","authenticated-orcid":false,"given":"E.","family":"Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Hospital Universitari Germans Trias i Pujol  Badalona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3182-9570","authenticated-orcid":false,"given":"L.","family":"M\u00e1rquez\u2010Mosquera","sequence":"additional","affiliation":[{"name":"Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy113"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000123991.13937.7e"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S268262"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.6.567"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2009.07.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182961626"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14563"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000162479.74277.86"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000483"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.328"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)84225-X"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32980"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000784"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20060"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21249"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2013.03.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835ddb85"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010995359"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(94)90248\u20108"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02053857"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200209000-00008"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.03.027"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.05.007"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010024\u201000916\u2010w"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad120"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132885"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000767"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjab029"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv099"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1564361"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03171-5"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1922746"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:38:28Z","timestamp":1790059108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":34,"alternative-id":["10.1111\/jgh.70745"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70745","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2025-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jgh.70745"}}