{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:56:23Z","timestamp":1790553383985,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017635","name":"Korean College of Helicobacter and Upper Gastrointestinal Research","doi-asserted-by":"publisher","award":["2023020003"],"award-info":[{"award-number":["2023020003"]}],"id":[{"id":"10.13039\/501100017635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Although clarithromycin resistance is a major cause of empirical triple therapy failure for\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication, the clinical relevance of amoxicillin susceptibility remains uncertain. We first compared eradication outcomes between empirical and susceptibility\u2010guided tailored triple therapy and then evaluated the influence of treatment duration and amoxicillin susceptibility among patients with clarithromycin\u2010susceptible strains receiving tailored triple therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively analyzed 807 patients receiving empirical or susceptibility\u2010guided tailored triple therapy in Korea from 2020 to 2024. Eradication outcomes were assessed in modified intention\u2010to\u2010treat (mITT) and per\u2010protocol (PP) populations by antibiotic susceptibility and treatment duration.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eradication rates were higher with tailored than empirical triple therapy (mITT: 92.9% vs. 69.3%,\n p<\/jats:italic>\n \u2009<\u20090.001; PP: 93.7% vs. 69.7%,\n p<\/jats:italic>\n \u2009<\u20090.001). Among patients with clarithromycin\u2010susceptible strains receiving tailored triple therapy, eradication rates were higher in amoxicillin\u2010susceptible than in amoxicillin\u2010resistant strains in the mITT analysis (94.0% vs. 86.8%,\n p<\/jats:italic>\n \u2009=\u20090.034), whereas the difference was not statistically significant in the PP analysis (94.5% vs. 89.4%,\n p<\/jats:italic>\n \u2009=\u20090.118). In the PP population, eradication rates did not differ significantly according to treatment duration in either amoxicillin\u2010susceptible (\n p<\/jats:italic>\n \u2009=\u20090.073) or amoxicillin\u2010resistant strains (\n p<\/jats:italic>\n \u2009=\u20090.884).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Among patients with clarithromycin\u2010susceptible strains receiving tailored triple therapy, eradication rates did not differ significantly according to treatment duration. However, these findings should be interpreted cautiously because the study may have been underpowered to detect modest but clinically meaningful differences. Amoxicillin susceptibility may be associated with eradication outcomes, although the statistical robustness of this association remains limited.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.70758","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:29:27Z","timestamp":1790551767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Susceptibility\u2010Guided Triple Therapy Achieves High\n \n Helicobacter pylori<\/i>\n <\/scp>\n Eradication Regardless of Duration"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-6327","authenticated-orcid":false,"given":"Hoyoung","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Soonchunhyang University Seoul Hospital Soonchunhyang University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-3744","authenticated-orcid":false,"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-9099","authenticated-orcid":false,"given":"Hee Kyong","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3771-3691","authenticated-orcid":false,"given":"Kee Wook","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-7585","authenticated-orcid":false,"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-4683","authenticated-orcid":false,"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-4109","authenticated-orcid":false,"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-8794","authenticated-orcid":false,"given":"Ho June","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3776-3928","authenticated-orcid":false,"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-5859","authenticated-orcid":false,"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-7519","authenticated-orcid":false,"given":"Jung Mogg","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology Hanyang University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"A Review of Human Carcinogens: Part B: Biological Agents","author":"IARC IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori Infection and the Development of Gastric Cancer","volume":"345","author":"Uemura N.","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_4_1","first-page":"229","article-title":"Global Cancer 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H.","year":"2025","journal-title":"Cancer Research and Treatment"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12592","article-title":"Nationwide Antibiotic Resistance Mapping of Helicobacter pylori in Korea: A Prospective Multicenter Study","volume":"24","author":"Lee J. H.","year":"2019","journal-title":"Helicobacter"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5009\/gnl20288","article-title":"Evidence\u2010Based Guidelines for the Treatment of Helicobacter pylori Infection in Korea 2020","volume":"15","author":"Jung H. K.","year":"2021","journal-title":"Gut Liver"},{"key":"e_1_2_11_8_1","volume-title":"Breakpoint Tables for Interpretation of MICs and Zone Diameters","author":"The European Committee on Antimicrobial Susceptibility Testing","year":"2025"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5009\/gnl250119","article-title":"Establishing Epidemiological Cutoff Values for Helicobacter pylori Strains in Korea: A Model\u2010Based Analysis of Antibiotic Resistance Patterns","volume":"20","author":"Noh J. H.","year":"2026","journal-title":"Gut Liver"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/ajg.2014.222","article-title":"Pretreatment Antimicrobial Susceptibility\u2010Guided vs. Clarithromycin\u2010Based Triple Therapy for Helicobacter pylori Eradication in a Region With High Rates of Multiple Drug Resistance","volume":"109","author":"Park C. S.","year":"2014","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002750","article-title":"Tailored Therapy Versus Empiric Chosen Treatment for Helicobacter pylori Eradication: A Meta\u2010Analysis","volume":"95","author":"Chen H.","year":"2016","journal-title":"Medicine"},{"key":"e_1_2_11_12_1","first-page":"340","article-title":"Additive Effect of Pronase on the Eradication Rate of First\u2010Line Therapy for Helicobacter pylori Infection","volume":"9","author":"Bang C. S.","year":"2015","journal-title":"Gut Liver"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1523-5378.2007.00468.x","article-title":"Comparison of 7\u2010Day and 14\u2010Day Proton Pump Inhibitor\u2010Containing Triple Therapy for Helicobacter pylori Eradication: Neither Treatment Duration Provides Acceptable Eradication Rate in Korea","volume":"12","author":"Kim B. G.","year":"2007","journal-title":"Helicobacter"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of Helicobacter pylori Infection\u2014The Maastricht V\/Florence Consensus Report","volume":"66","author":"Malfertheiner P.","year":"2017","journal-title":"Gut"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.gastro.2016.04.006","article-title":"The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults","volume":"151","author":"Fallone C. 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M.","year":"2020","journal-title":"Antibiotics"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12941-022-00509-3","article-title":"Heteroresistance to Clarithromycin and Metronidazole in Patients With a Helicobacter pylori Infection: A Systematic Review and Meta\u2010Analysis","volume":"21","author":"Kouhsari E.","year":"2022","journal-title":"Annals of Clinical Microbiology and Antimicrobials"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:29:30Z","timestamp":1790551770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":19,"alternative-id":["10.1111\/jgh.70758"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70758","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jgh.70758"}}