{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:01:18Z","timestamp":1790035278497,"version":"4.0.1"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Obesity therapeutics is rapidly evolving, and mechanistic frameworks linking the gut microbiome to systemic metabolism are essential for clinical translation. In this letter, I commend the invited review by Mao et\u00a0al., which elegantly integrates mechanistic insights across the gut\u2013brain, gut\u2013adipose, and gut\u2013pancreas axes, and we propose three extensions to strengthen its clinical relevance. First, I highlight the bidirectional interplay between GLP\u20101 receptor agonists (GLP\u20101 RAs)\u2014now first\u2010line obesity pharmacotherapy\u2014and the gut microbiome: GLP\u20101 RAs enrich\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    <\/jats:styled-content>\n                    and short\u2010chain\u2010fatty\u2010acid\u2010producing taxa, while baseline microbiome composition modulates individual drug responsiveness. Second, I argue for greater attention to upper gastrointestinal microbial niches and synthetic biology approaches, including engineered\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Clostridium butyricum<\/jats:italic>\n                    <\/jats:styled-content>\n                    strains that secrete GLP\u20101 locally within the intestinal lumen. Third, I emphasize the circadian dimension of the gut\u2013endocrine axis\u2014time\u2010restricted feeding restores microbial diurnal oscillations\u2014and its integration with phenotype\u2010guided precision medicine (e.g., \u201chungry gut,\u201d \u201chungry brain,\u201d and \u201cemotional hunger\u201d subtypes). Incorporating these perspectives would transform the review into a practical roadmap for personalized obesity intervention.\n                  <\/jats:p>","DOI":"10.1111\/jgh.70772","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:10:35Z","timestamp":1790032235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Letter to the Editor: The Gut Microbiome\u2013Endocrine Axis in Obesity: Mechanisms and Therapeutics"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-1250","authenticated-orcid":false,"given":"Jin\u2010Bo","family":"Su","sequence":"first","affiliation":[{"name":"Endocrine Department Quanzhou First Hospital Affiliated to Fujian Medical University  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_1_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.70511"},{"key":"e_1_2_1_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17081303"},{"key":"e_1_2_1_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2456592"},{"key":"e_1_2_1_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102573"},{"key":"e_1_2_1_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751\u20107915.14196"},{"key":"e_1_2_1_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101801"},{"key":"e_1_2_1_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23120"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.70772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.70772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:10:37Z","timestamp":1790032237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.70772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":7,"alternative-id":["10.1111\/jgh.70772"],"URL":"https:\/\/doi.org\/10.1111\/jgh.70772","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2026-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jgh.70772"}}