{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:02:59Z","timestamp":1790640179000,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>METTL1\u2010mediated m7G modification plays a procancer role in various malignant tumors, but whether it promotes the progression of esophageal squamous cell carcinoma (ESCC) by regulating the DNA replication factor GINS2 and tumor\u2010associated macrophage polarization remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The expression and function of GINS2 were examined through in\u00a0vitro and in\u00a0vivo experiments. RIP, MeRIP, and RNA stability assays were used to validate the regulatory effect of METTL1 on GINS2 modification. The impact on macrophage polarization was explored using a coculture system and STAT3 agonist Colivelin rescue experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GINS2 was highly expressed in ESCC. Knockdown of GINS2 inhibited the malignant phenotypes of tumor cells and reversed epithelial\u2013mesenchymal transition (EMT). Mechanistically, METTL1 enhanced the stability of GINS2 mRNA through m7G modification, thereby activating the STAT3 pathway and inducing M2 polarization of macrophages. The STAT3 agonist Colivelin partially reversed the tumor\u2010suppressive effects induced by GINS2 knockdown. In\u00a0vivo knockdown of GINS2 suppressed tumor growth and M2 infiltration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>METTL1\u2010mediated m7G modification stabilizes GINS2 mRNA, activates the STAT3 pathway, induces M2 polarization, and promotes ESCC progression. This axis provides a novel potential diagnostic and therapeutic target for ESCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70777","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:40:23Z","timestamp":1790638823000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["METTL1\u2010Mediated m7G Modification of GINS2 mRNA Activates STAT3 to Drive Esophageal Squamous Cell Carcinoma Progression"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1389-6833","authenticated-orcid":false,"given":"Wu","family":"Han","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-9075","authenticated-orcid":false,"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-026-04310-6","article-title":"Unraveling the Complexity of Pyroptosis in Esophageal Cancer: From Underlying Mechanisms to Targeted Therapies","volume":"26","author":"Yang W.","year":"2026","journal-title":"Cancer Cell International"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2026.168267","article-title":"Heterogeneous Nuclear Ribonucleoprotein C Deficiency Compromises Extracellular Matrix\u2010Receptor Interaction and Induces Apoptosis in Esophageal Cancer by Targeting Transcripts With Complex Structures","volume":"1872","author":"Ding G.","year":"2026","journal-title":"Biochimica et Biophysica Acta (BBA) \u2010 Molecular Basis of Disease"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003729","article-title":"Casein Kinase 2\u2010Mediated Phosphorylation of the Splicing Factor SF3B3 Plays a Key Role in Esophageal Squamous Cell Carcinoma Progression","volume":"24","author":"Wang D. 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