{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:53:44Z","timestamp":1790902424675,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pharmacologic therapies to prevent decompensation in cirrhosis remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the association between aspirin use and cirrhosis\u2010related outcomes and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized deidentified electronic health records from a global federated network (January 2013\u2013July 2025). Adults with cirrhosis without decompensation in the preceding 12\u2009months and without prior HCC were included. Following 1:1 propensity score matching, outcomes were assessed at 12, 24, and 36\u2009months. The primary outcome was a composite of cirrhosis\u2010related decompensation (ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatorenal syndrome, encephalopathy). Secondary outcomes included hepatocellular carcinoma (HCC), mortality, and gastrointestinal bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 458\u2009165 patients, matching yielded 25\u2009782 patients (12\u2009891 per group; mean age 63.3\u2009years). Aspirin was associated with a lower risk of the composite outcome at 12 (HR, 0.75; 95% CI, 0.67\u20130.83), 24 (HR, 0.76; 95% CI, 0.70\u20130.84), and 36\u2009months (HR, 0.77; 95% CI, 0.68\u20130.84), driven by reduced variceal bleeding, spontaneous bacterial peritonitis, and ascites. Absolute risks were 17.8% vs. 22.7% at 12\u2009months, 20.4% vs. 24.7% at 24\u2009months, and 22.0% vs. 25.7% at 36\u2009months. At 12\u2009months, the NNT was 21 for the composite outcome and 20 for mortality. Despite an increased risk of nonvariceal bleeding (NNH 143 at 12\u2009months), serving as a positive control outcome, aspirin demonstrated a net clinical benefit, with more pronounced benefits in high cardiovascular risk patients (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aspirin use is associated with reduced cirrhosis complications, HCC, and mortality, suggesting a potential role in the management of compensated cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70780","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:46Z","timestamp":1790899246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Aspirin With Improved Clinical Outcomes and Survival in Patients With Compensated Cirrhosis: A Propensity Score\u2010Matched Study of 25\u2009782 Individuals"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-2192","authenticated-orcid":false,"given":"Shahem","family":"Abbarh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine MedStar Health Georgetown University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-619X","authenticated-orcid":false,"given":"Bisher","family":"Sawaf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Toledo  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-4728","authenticated-orcid":false,"given":"Tiago Lemos","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Dresden International University  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen B.","family":"Huttner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-1415","authenticated-orcid":false,"given":"Annahita","family":"Sedghi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD Dresden University of Technology  Dresden 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