{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:02:37Z","timestamp":1790769757899,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Ultra\u2010low\u2010volume polyethylene glycol (PEG) with ascorbic acid (Asc) improves tolerability, but Asc\u2010related gastrointestinal and metabolic adverse events remain a concern. Whether reducing the Asc dose preserves cleansing efficacy without compromising safety is unclear. We compared a modified 1\u2010L PEG regimen with reduced Asc (1\u2010L PEG\u2009+\u2009low Asc) with standard 1\u2010L PEG\u2009+\u2009Asc and 2\u2010L PEG\u2009+\u2009Asc formulations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, randomized, investigator\u2010blinded, three\u2010arm noninferiority trial across five hospitals, low\u2010risk adults undergoing colonoscopy were allocated (1:1:1) to 1\u2010L PEG\u2009+\u2009low Asc, 1\u2010L PEG\u2009+\u2009Asc, or 2\u2010L PEG\u2009+\u2009Asc. The primary endpoint was successful bowel cleansing by the Harefield Cleansing Scale (HCS). Secondary endpoints included Boston Bowel Preparation Scale (BBPS), endoscopic outcomes, gastric residual volume quantified by esophagogastroduodenoscopy, patient\u2010reported tolerability, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 242 per\u2010protocol participants, HCS\u2010defined successful cleansing was achieved in 92.7% with 1\u2010L PEG\u2009+\u2009low Asc, 100.0% with 1\u2010L PEG\u2009+\u2009Asc, and 98.7% with 2\u2010L PEG\u2009+\u2009Asc (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). The low\u2010Asc regimen met noninferiority criteria versus both comparators (risk difference vs. 1\u2010L PEG\u2009+\u2009Asc, \u22127.3%; 97.5% CI, \u221213.0 to \u22121.6). BBPS\u2010defined success, adenoma detection rate (31.7%, 18.1%, and 20.8%), gastric fluid volume (27.4, 28.2, and 25.2\u2009mL), and willingness to repeat the regimen (78.0%, 73.5%, and 71.4%) were similar across groups. Adverse\u2010event rates were comparable, with no electrolyte disturbances or renal events observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A modified 1\u2010L PEG regimen with reduced Asc provides bowel cleansing efficacy noninferior to both standard 1\u2010L and 2\u2010L PEG\u2009+\u2009Asc preparations, with comparable tolerability and safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70781","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:35:57Z","timestamp":1790768157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of 1\u2010L Polyethylene Glycol With Low Ascorbic Acid for Bowel Preparation: A Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5272-4293","authenticated-orcid":false,"given":"Ji\u00a0Eun","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Internal Medicine St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-2633","authenticated-orcid":false,"given":"Hyo\u00a0Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u00a0Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-7896","authenticated-orcid":false,"given":"Sang\u2010Bum","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-4136","authenticated-orcid":false,"given":"Bo\u2010In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-4553","authenticated-orcid":false,"given":"Kang\u2010Moon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Vincent's Hospital, College of Medicine, The Catholic University of Korea  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g2467","article-title":"Effect of Screening Sigmoidoscopy and Screening Colonoscopy on Colorectal Cancer Incidence and Mortality: Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials and Observational Studies","volume":"348","author":"Brenner H.","year":"2014","journal-title":"BMJ"},{"issue":"3","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","article-title":"ACG Clinical Guidelines: Colorectal Cancer Screening 2021","volume":"116","author":"Shaukat A.","year":"2021","journal-title":"American Journal of Gastroenterology"},{"issue":"2","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2015.5","article-title":"Colonoscopy: Quality Indicators","volume":"6","author":"Anderson J. 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N.","year":"2022","journal-title":"Gastrointestinal Endoscopy"},{"issue":"6","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099092","article-title":"A Meta\u2010Analysis of Randomized Controlled Trials of Low\u2010Volume Polyethylene Glycol Plus Ascorbic Acid Versus Standard\u2010Volume Polyethylene Glycol Solution as Bowel Preparations for Colonoscopy","volume":"9","author":"Xie Q.","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/den.14015","article-title":"Efficacy of Ultra\u2010Low Volume (\u22641\u2009L) Bowel Preparation Fluids: Systematic Review and Meta\u2010Analysis","volume":"34","author":"Riswijk M. L. 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Z.","year":"2021","journal-title":"Frontiers in Medicine (Lausanne)"},{"issue":"6","key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.dld.2017.01.167","article-title":"Evaluation of Clensia(), a New Low\u2010Volume PEG Bowel Preparation in Colonoscopy: Multicentre Randomized Controlled Trial Versus 4L PEG","volume":"49","author":"Spada C.","year":"2017","journal-title":"Digestive and Liver Disease"},{"issue":"4","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.14309\/ajg.0000000000003287","article-title":"Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi\u2010Society Task Force on Colorectal Cancer","volume":"120","author":"Jacobson B. 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