{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:43:30Z","timestamp":1792651410599,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of cardiometabolic risk factors (CMRFs) on the cardiovascular\u2013kidney\u2013metabolic (CKM) axis in chronic hepatitis B (CHB) remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective analysis enrolling patients with CHB who were on nucleos(t)ide analogues (NUCs). CMRFs were defined as per established criteria; poorly\u2010controlled CMRFs were defined with specific cut\u2010offs measured across 5\u2009years. Study outcomes include fibrosis progression (liver stiffness [LS] increase by \u2265\u200920%), liver\u2010related events (LREs), chronic kidney disease (CKD) progression, major adverse cardiovascular events (MACE), and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 714 NUC\u2010treated patients (median age: 61.0 [54.5\u201366.7] years; 69.6% male; 90.5% undetectable HBV DNA, median NUCs duration of 14.1 [11.3\u201316.5] years) were followed up for 9.7 (7.2\u201310.2) years. LREs occurred in 112 (15.7%) patients, with annual incidence rate of 1.62 events per 100 person\u2010years. All\u2010cause mortality was observed in 86 (12%) patients, including 47 (6.6%) liver\u2010related mortality. The number or types of CMRFs did not display a linear positive relationship with adverse clinical outcomes. The presence of \u2265\u20091 poorly controlled CMRFs is independently associated with LREs (aHR: 2.001, 95% CI: 1.350\u20132.965), MACE (aHR: 1.042, 95% CI: 1.030\u20131.081), and all\u2010cause mortality (aHR: 2.082, 95% CI: 1.006\u20134.310), whereas patients having \u2265\u20092 and \u2265\u20093 poorly controlled CMRFs are independently associated with CKD progression (aOR: 1.887, 95% CI: 1.115\u20133.221) and fibrosis progression (aOR: 1.624, 95% CI: 1.164\u20132.266), respectively. The results remain robust in patients without advanced fibrosis (LS\u2009\u2264\u200910\u2009kPa) at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Active optimization of CMRFs should be an integral component of CHB management in addition to NUCs therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70828","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:13:12Z","timestamp":1792649592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Cardiometabolic Risk Factors Control on Cardiovascular\u2013Kidney\u2013Metabolic Axis in Chronic Hepatitis B"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-6123","authenticated-orcid":false,"given":"Karen Cheuk\u2010Ying","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pok Fu Lam Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-7539","authenticated-orcid":false,"given":"Rex Wan\u2010Hin","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital The University of Hong Kong  Pok Fu Lam Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-4479","authenticated-orcid":false,"given":"Matthew Shing\u2010Hin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine The University of Hong Kong  Pok Fu Lam Hong Kong, 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