{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:40:31Z","timestamp":1792492831305,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112\u20102314\u2010B\u2010002\u2010205\u2010MY3"],"award-info":[{"award-number":["NSTC 112\u20102314\u2010B\u2010002\u2010205\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010002\u2010241"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010002\u2010241"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Steatotic liver disease (SLD) may lead to advanced liver diseases. We aimed to identify clinical risk factors for advanced fibrosis in pathology\u2010proven SLD patients in a hepatitis B virus (HBV) endemic population, with emphasis on nonelder subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult SLD patients diagnosed via pathology at National Taiwan University Hospital between June 2009 and December 2023 were recruited. Advanced fibrosis was defined as F2 to F4 fibrosis. Patients were stratified by age (&lt;\u200950\u2009years defined as nonelder), metabolic dysfunction\u2010associated steatotic liver disease (MASLD), and HBV infection. Clinical risk factors for advanced fibrosis and at\u2010risk steatohepatitis were investigated, and the predictive performance of noninvasive scores was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 223 pathology\u2010proven SLD patients, older age (odds ratio [OR]: 1.04), alcohol consumption (OR: 5.77), type 2 diabetes mellitus (T2DM) (OR: 2.13), chronic HBV infection (OR: 2.52), and obesity (OR: 2.64) were independent risk factors for advanced fibrosis. In the nonelder subgroup, older age (OR: 1.10) and obesity (OR: 3.75) were significant. In the MASLD subgroup, older age (OR: 1.04), hypertension (OR: 2.31), T2DM (OR: 3.07), and chronic HBV infection (OR: 3.59) remained significant. Obesity (OR: 4.14) was a significant risk factor for at\u2010risk steatohepatitis in the nonelder subgroup. NAFLD fibrosis score had the highest AUROC (0.724) for advanced fibrosis in the entire cohort, while FIB\u20104 performed best in nonelder subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older age, alcohol, T2DM, chronic HBV infection, and obesity were associated with advanced fibrosis. Risk factors and noninvasive score performance varied in nonelder subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.70837","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:06:54Z","timestamp":1792490814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Risk Factors for Advanced Fibrosis in Pathology\u2010Proven Steatotic Liver Disease: Emphasis on Nonelder Subjects"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-2537","authenticated-orcid":false,"given":"Chen\u2010Te","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University BioMedical Park Hospital  Hsinchu 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Hospital Medicine, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-9707","authenticated-orcid":false,"given":"Chen\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Chih","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Hepatitis Research Center National Taiwan University Hospital  Taipei 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