{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:50Z","timestamp":1790812850528,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T00:00:00Z","timestamp":1357862400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","award":["U19 HL91179-01"],"award-info":[{"award-number":["U19 HL91179-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","award":["1RC1HL099395"],"award-info":[{"award-number":["1RC1HL099395"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["U01HL105268"],"award-info":[{"award-number":["U01HL105268"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["K01AG33643"],"award-info":[{"award-number":["K01AG33643"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine whether the total burden of comorbidity and pattern of co\u2010occurring conditions varies in individuals with heart failure (\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      ) with preserved left ventricular ejection fraction (\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      ) (\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010P) or\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      with reduced\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010R).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Four participating health plans within the National Heart, Lung, and Blood Institute\u2013sponsored Cardiovascular Research Network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      All members aged 65 and older with\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      based on hospital discharge and ambulatory visit diagnoses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Participants with a\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      of 50% or greater were classified as having\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010P. Presence of cardiac and noncardiac comorbidities was obtained from health plan administrative databases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 23,435 individuals identified with\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      information, 53% (12,407) had confirmed\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010P (mean age 79.6; 60% female). More than three\u2010quarters of the sample had three or more co\u2010occurring conditions in addition to\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      , and half had five or more cooccurring conditions. Participants with\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010P had a slightly higher burden of comorbidity than those with\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      \u2010R (mean 4.5 vs 4.4,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.002). Patterns of how specific conditions co\u2010occurred did not vary in participants with preserved or reduced systolic function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      There is a high degree of comorbidity and multiple morbidity in individuals with\n                      <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                      . The burden and pattern of comorbidity varies only slightly in individuals with preserved or reduced\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12062","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T13:56:29Z","timestamp":1357912589000},"page":"26-33","source":"Crossref","is-referenced-by-count":74,"title":["Patterns of Comorbidity in Older Adults with Heart Failure: The Cardiovascular Research Network\n                    <scp>PRESERVE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Jane S.","family":"Saczynski","sequence":"first","affiliation":[{"name":"Meyers Primary Care Institute and Fallon Community Health Plan Worcester Massachusetts"},{"name":"Division of UMass Medical School Geriatric Medicine University of Massachusetts Worcester 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