{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:57:47Z","timestamp":1793890667170,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Aging, National Institutes of Health","award":["1RO1AG031795-03"],"award-info":[{"award-number":["1RO1AG031795-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine whether intraoperative blood transfusion, a known trigger and amplifier of inflammation, is an independent risk factor for early postoperative delirium (\n                      <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>\n                      ), an acute state of confusion with fluctuating consciousness and inattention after surgery, in older adults undergoing surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Secondary analysis using a database created for a prospective cognitive outcomes study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Four hundred seventy\u2010two individuals aged 65 and older undergoing major noncardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Perioperative data were examined for association with\n                      <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>\n                      on the first postoperative day. Multivariable logistic regression analysis was conducted to determine whether intraoperative blood transfusion independently predicts\n                      <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>\n                      after adjusting for covariates known to be associated with onset of delirium and blood transfusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred thirty\u2010seven individuals (29%) developed delirium on the first postoperative day. The multivariable logistic regression model identified age, sex, history of central nervous system disorder, preoperative cognitive dysfunction, and pain, as well as blood transfusions, as independent risk factors for\n                      <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>\n                      . Intraoperative administration of more than 1,000\u00a0mL of red blood cells (\n                      <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                      s) was the strongest predictor of\n                      <jats:styled-content style=\"fixed-case\">POD<\/jats:styled-content>\n                      on the first postoperative day (odds ratio\u00a0=\u00a03.68; 95% confidence interval\u00a0=\u00a01.32\u201310.94;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Intraoperative blood transfusion of more than 1,000\u00a0mL of\n                      <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                      s increases the risk of delirium on the first postoperative day in older adults undergoing noncardiac surgery.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12143","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T00:22:44Z","timestamp":1363393364000},"page":"365-370","source":"Crossref","is-referenced-by-count":69,"title":["Association Between Intraoperative Blood Transfusions and Early Postoperative Delirium in Older Adults"],"prefix":"10.1111","volume":"61","author":[{"given":"Matthias","family":"Behrends","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"DePalma","sequence":"additional","affiliation":[{"name":"Department of Statistics West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sands","sequence":"additional","affiliation":[{"name":"School of Nursing Purdue University West Lafayette Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California at San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890009011770"},{"key":"e_1_2_6_3_1","first-page":"448","article-title":"Postoperative delirium","volume":"77","author":"Whitlock EL","year":"2011","journal-title":"Minerva 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