{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:01:06Z","timestamp":1762506066997,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Development Regional Fund"},{"name":"Spanish Network for the Research in Infectious Diseases","award":["REIPI RD06\/0008"],"award-info":[{"award-number":["REIPI RD06\/0008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,3]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus\n A<\/jats:styled-content>\n (\n H<\/jats:styled-content>\n 1\n N<\/jats:styled-content>\n 1) admitted to the intensive care unit (\n ICU<\/jats:styled-content>\n ) and to identify independent predictors of\n ICU<\/jats:styled-content>\n mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza\n A<\/jats:styled-content>\n (\n H<\/jats:styled-content>\n 1\n N<\/jats:styled-content>\n 1) admitted to the\n ICU<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n One hundred forty\u2010eight\n S<\/jats:styled-content>\n panish\n ICU<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Individuals with influenza\n A<\/jats:styled-content>\n (\n H<\/jats:styled-content>\n 1\n N<\/jats:styled-content>\n 1) confirmed using real\u2010time polymerase chain reaction from\n A<\/jats:styled-content>\n pril 2009 to\n J<\/jats:styled-content>\n uly 2011.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One thousand one hundred twenty individuals (129 (11.5%) aged \u226565) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%,\n P<\/jats:italic>\n \u00a0<\u00a0.001). In older individuals,\n A<\/jats:styled-content>\n cute\n P<\/jats:styled-content>\n hysiology and\n C<\/jats:styled-content>\n hronic\n H<\/jats:styled-content>\n ealth\n E<\/jats:styled-content>\n valuation\n II<\/jats:styled-content>\n score (odds ratio (\n OR<\/jats:styled-content>\n )\u00a0=\u00a01.11, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.11\u20131.20,\n P\u00a0<\/jats:italic>\n =\u00a0.002), immunosuppression (\n OR<\/jats:styled-content>\n \u00a0=\u00a03.66, 95%\n CI<\/jats:styled-content>\n , 1.33\u201310.03,\n P<\/jats:italic>\n \u00a0=\u00a0.01) and oseltamivir therapy initiated after 48\u00a0hours (\n OR<\/jats:styled-content>\n \u00a0=\u00a03.32, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.02\u201310.8,\n P<\/jats:italic>\n \u00a0=\u00a0.04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (\n OR<\/jats:styled-content>\n \u00a0=\u00a02.39, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.98\u20135.91,\n P<\/jats:italic>\n \u00a0=\u00a0.06).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Individuals aged 65 and older with influenza\n A<\/jats:styled-content>\n (\n H<\/jats:styled-content>\n 1\n N<\/jats:styled-content>\n 1) admitted to the\n ICU<\/jats:styled-content>\n have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12152","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T00:23:03Z","timestamp":1363393383000},"page":"350-356","source":"Crossref","is-referenced-by-count":19,"title":["Epidemiology, Clinical Features, and Prognosis of Elderly Adults with Severe Forms of Influenza\n A<\/scp>\n (\n H<\/scp>\n 1\n N<\/scp>\n 1)"],"prefix":"10.1111","volume":"61","author":[{"given":"Jos\u00e9","family":"Garnacho\u2010Montero","sequence":"first","affiliation":[{"name":"Critical Care and Emergency Department Hospital Virgen del Roc\u00edo Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Guti\u00e9rrez\u2010Pizarraya","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Microbiology, and Preventive Medicine Institute of Biomedicine of Seville University of Seville, Spanish Network for the Research in Infectious Diseases Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Critical Care and Emergency Department Hospital Virgen del Roc\u00edo Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Hospital Universitario Dr. Peset Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Granada","sequence":"additional","affiliation":[{"name":"Critical Care Department Hospital Universitario de Bellvitge Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Ruiz\u2010Santana","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Hospital Universitario de Gran Canaria Dr. Negrin Las Palmas de Gran Canaria 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