{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:28:27Z","timestamp":1765700907564,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["KL2RR025770","R03 AG043906-01"],"award-info":[{"award-number":["KL2RR025770","R03 AG043906-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["P60 AR 47782"],"award-info":[{"award-number":["P60 AR 47782"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01 HL106029"],"award-info":[{"award-number":["R01 HL106029"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical and Translational Science Institute at Boston University","award":["KL2RR025770"],"award-info":[{"award-number":["KL2RR025770"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grant","doi-asserted-by":"crossref","award":["R03 AG043906-01"],"award-info":[{"award-number":["R03 AG043906-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To identify older adults with comorbidities or poor functional status at high risk of postoperative venous thromboembolism (\n VTE<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Veterans Affairs Medical Center (\n VAMC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Older adults who underwent total hip and knee replacement (\n THR<\/jats:styled-content>\n and\n TKR<\/jats:styled-content>\n ) from 2002 to 2009.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Using multivariate logistic regression, the independent effect of cardiopulmonary comorbidities and diabetes on\n VTE<\/jats:styled-content>\n was analyzed. Functional status expressed in a summary physical component score (\n PCS<\/jats:styled-content>\n ) was also analyzed in a subset of individuals in whom information on it was available.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 23,326\n THR<\/jats:styled-content>\n and\n TKR<\/jats:styled-content>\n surgeries performed at the\n VAMC<\/jats:styled-content>\n during the study period. Individuals with chronic obstructive pulmonary disease (\n COPD<\/jats:styled-content>\n ) had a 25% greater risk of\n VTE<\/jats:styled-content>\n (odds ratio (\n OR<\/jats:styled-content>\n )\u00a0=\u00a01.25, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.06\u20131.48), whereas those with coronary artery disease, congestive heart failure, and cerebrovascular disease did not have a greater risk of\n VTE<\/jats:styled-content>\n . Individuals with diabetes mellitus had a lower risk of\n VTE<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n \u00a0=\u00a00.77, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.64\u20130.92). Individuals with low\n PCS<\/jats:styled-content>\n , which were available for 3,169 patients, had a 62% greater risk, although the effect did not reach statistical significance (lowest vs highest quartile\n OR<\/jats:styled-content>\n \u00a0=\u00a01.62, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.93\u20132.80).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Individuals with\n COPD<\/jats:styled-content>\n had slightly greater risk of\n VTE<\/jats:styled-content>\n , whereas low functional status had a larger effect that did not reach statistical significance. The constraints of administrative data analysis and sample size available for\n PCS<\/jats:styled-content>\n limit conclusions about the role of these comorbidities and functional status.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12161","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T06:10:17Z","timestamp":1364451017000},"page":"590-601","source":"Crossref","is-referenced-by-count":9,"title":["Venous Thromboembolism After Joint Replacement in Older Male Veterans with Comorbidity"],"prefix":"10.1111","volume":"61","author":[{"given":"Alok","family":"Kapoor","sequence":"first","affiliation":[{"name":"Hospital Medicine Unit School of Medicine Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Chew","sequence":"additional","affiliation":[{"name":"Center for Health Quality, Outcomes, and Economic Research Edith Nourse Rogers Memorial Veterans Affairs Hospital Bedford Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Silliman","sequence":"additional","affiliation":[{"name":"Section of Geriatrics School of Medicine Boston University Boston Massachusetts"},{"name":"Department of Epidemiology Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine M.","family":"Hylek","sequence":"additional","affiliation":[{"name":"Section of General Internal Medicine School of Medicine Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Division of Rheumatology, Immunology, and Allergy Orthopedic and Arthritis Center for Outcomes Research Brigham and Women's Hospital Boston Massachusetts"},{"name":"Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Berlowitz","sequence":"additional","affiliation":[{"name":"Center for Health Quality, Outcomes, and Economic Research Edith Nourse Rogers Memorial Veterans Affairs Hospital Bedford Massachusetts"},{"name":"School of Public Health Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.12.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/590124"},{"key":"e_1_2_7_4_1","first-page":"e418","article-title":"ACC\/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery","volume":"116","author":"Fleisher LA","year":"2007","journal-title":"Circulation"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.140.12.1210"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61526-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S1401"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00882"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.10.034"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3364"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022157"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-63"},{"key":"e_1_2_7_13_1","unstructured":"Medical Outcomes Trust.The SF\u201012: An Even Shorter Health Survey.2009[on\u2010line]. 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