{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:00:29Z","timestamp":1772766029835,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate current clinical practice for octogenarians with iron\u2010deficiency anemia (\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      ) by assessing referral patterns, diagnostic choices, clinical consequences of omission of endoscopy, and risks and benefits of\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      \u2010related surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A regional hospital\u2010based laboratory in the Netherlands between January 2008 and December 2010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      All individuals aged 80 and older with newly ascertained\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      IDA was defined as a hemoglobin level of 11.1\u00a0g\/\n                      <jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>\n                      or less and a ferritin level of 25\u00a0\u03bcg\/L or less.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four hundred seventy\u2010one participants were newly diagnosed with\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      during the study period (median age 85.4), 276 of whom (59%) did not undergo any diagnostic procedures for\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      . A cause of anemia was identified during the initial examination in 50% of the 205 investigated participants, including nine (4%) upper and 37 (18%) lower gastrointestinal malignancies. Another 24 malignancies were identified during follow\u2010up, of which 16 were in the gastrointestinal tract, primarily in participants for whom the initial diagnostic examination was limited or omitted. Perioperative mortality was 15% in individuals with colon cancer. Median survival for participants with colon cancer was 2.2\u00a0years, and the survival benefit of surgery over supportive care was not apparent until 1.3\u00a0years after ascertainment of\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The omission of endoscopy for\n                      <jats:styled-content style=\"fixed-case\">IDA<\/jats:styled-content>\n                      and the omission of surgery for colon cancer occur frequently in octogenarians and seem appropriate in the presence of significant comorbidity and in cases in which there is limited life expectancy. Further research is needed to determine which baseline factors should guide decision\u2010making to optimize treatment outcomes and quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12168","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T01:42:54Z","timestamp":1364002974000},"page":"495-501","source":"Crossref","is-referenced-by-count":10,"title":["Diagnostic Choices and Clinical Outcomes in Octogenarians and Nonagenarians with Iron\u2010Deficiency Anemia in the Netherlands"],"prefix":"10.1111","volume":"61","author":[{"given":"Marije E.","family":"Hamaker","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Diakonessenhuis Utrecht\/Zeist\/Doorn Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tessa","family":"Acampo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Gelre Hospitals Apeldoorn the 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