{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:31:10Z","timestamp":1765827070948,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To investigate relationships between the use of cardiovascular medications, including angiotensin system\u2013blocking medications (\n                      <jats:styled-content style=\"fixed-case\">ASBM<\/jats:styled-content>\n                      s), orthostatic hypotension (\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      ), fall risk, and falls in community\u2010dwelling older people.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Sydney, Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Five hundred twenty community\u2010dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Medical, medication and falls history were obtained from a standardized questionnaire in all participants. Blood pressure was measured in supine, seated, and tilted positions. Fall risk was assessed using the Physiological Profile Assessment (\n                      <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>\n                      ). Falls data were collected prospectively for 12\u00a0months using monthly fall calendars. Participants were defined as nonfallers (no falls) and fallers (\u22651 falls) at the end of the 12\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants taking medications affecting the angiotensin system had greater quadriceps strength, but after adjusting for sex, this difference became insignificant. People taking\n                      <jats:styled-content style=\"fixed-case\">ASBM<\/jats:styled-content>\n                      s were less likely to fall (odds ratio\u00a0=\u00a00.68, 95% confidence interval\u00a0=\u00a00.48\u20130.97), and the association between\n                      <jats:styled-content style=\"fixed-case\">ASBM<\/jats:styled-content>\n                      s and falls remained significant after adjusting for sex, body mass index,\n                      <jats:styled-content style=\"fixed-case\">PPA<\/jats:styled-content>\n                      score, and psychotropic medication and 3\u2010hydroxy\u20103\u2010methyl\u2010glutaryl\u2010coenzyme A reductase inhibitor (statin) use.\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      was more frequently observed in participants taking alpha adrenergic receptor blockers (\u03b1\u2010blockers), but the presence of\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      did not increase fall risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The use of cardiovascular medications in older people did not increase the risk of falls, and the use of\n                      <jats:styled-content style=\"fixed-case\">ASBM<\/jats:styled-content>\n                      s was associated with lower fall risk. The mechanisms for this apparent protective effect are unclear and appear not to be directly related to muscle strength. More research is required to elucidate the possible protective effects of certain cardiovascular medications in relation to falls in older people.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12205","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T12:15:29Z","timestamp":1367324129000},"page":"776-781","source":"Crossref","is-referenced-by-count":36,"title":["Angiotensin System\u2013Blocking Medications Are Associated with Fewer Falls over 12 Months in Community\u2010Dwelling Older People"],"prefix":"10.1111","volume":"61","author":[{"given":"Alfred K. W.","family":"Wong","sequence":"first","affiliation":[{"name":"Falls and Balance Research Group, Neuroscience Research Australia University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Lord","sequence":"additional","affiliation":[{"name":"Falls and Balance Research Group, Neuroscience Research Australia University of New South Wales Sydney NSW Australia"},{"name":"School of Public Health and Community Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina L.","family":"Sturnieks","sequence":"additional","affiliation":[{"name":"Falls and Balance Research Group, Neuroscience Research Australia University of New South Wales Sydney NSW Australia"},{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Delbaere","sequence":"additional","affiliation":[{"name":"Falls and Balance Research Group, Neuroscience Research Australia University of New South Wales Sydney NSW Australia"},{"name":"School of Public Health and Community Medicine University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian N.","family":"Trollor","sequence":"additional","affiliation":[{"name":"Centre for Healthy Brain Ageing University of New South Wales Sydney NSW Australia"},{"name":"Department of Developmental Disability Neuropsychiatry, School of Psychiatry University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline C. 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