{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:38:39Z","timestamp":1788262719825,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pittsburgh Claude D. Pepper Older American's Independence Center","award":["P30 AG024827"],"award-info":[{"award-number":["P30 AG024827"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,5]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine whether white matter hyperintensities (\n WMH<\/jats:styled-content>\n s) on brain magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) in tracts in older adults with mobility impairment are linked to outcomes of gait rehabilitation interventions.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Twelve\u2010week randomized controlled single\u2010blind trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University\u2010based mobility research laboratory.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Ambulatory adults aged 65 and older with mobility impairment.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n \n A conventional gait intervention focusing on walking, endurance, balance, and strength (\n WEBS<\/jats:styled-content>\n , n\u00a0=\u00a021) and a task\u2010oriented intervention focused on timing and coordination of gait (\n TC<\/jats:styled-content>\n , n\u00a0=\u00a023).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Self\u2010paced gait speed was measured over an instrumented walkway before and after the intervention, and\n WMH<\/jats:styled-content>\n and brain volumes were quantified on preintervention brain\n MRI<\/jats:styled-content>\n using an automated segmentation process. A white matter tract atlas was overlaid on the segmented images to measure tract\n WMH<\/jats:styled-content>\n volumes, and\n WMH<\/jats:styled-content>\n volumes were normalized to total brain volume. Aggregate\n WMH<\/jats:styled-content>\n volumes in all white matter tracts and individual\n WMH<\/jats:styled-content>\n volumes in specific longitudinal tracts (superior longitudinal fasciculus, inferior longitudinal fasciculus, and fronto\u2010occipital fasciculus) and the cingulum were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Gait speed gains in the\n TC<\/jats:styled-content>\n group were of the same magnitude, independent of\n WMH<\/jats:styled-content>\n volume measures in all except the cingulum, but in the\n WEBS<\/jats:styled-content>\n group, gain in gait speed was smaller with greater overall tract\n WMH<\/jats:styled-content>\n volumes (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .001) and with greater\n WMH<\/jats:styled-content>\n volume in the three longitudinal tracts (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .001 to .02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Gains in gait speed with two types of gait rehabilitation are associated with individual differences in\n WMH<\/jats:styled-content>\n s. Task\u2010oriented therapy that targets timing and coordination of gait may particularly benefit older adults with\n WMH<\/jats:styled-content>\n s in brain tracts that influence gait and cognition.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12211","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T10:51:05Z","timestamp":1366109465000},"page":"686-693","source":"Crossref","is-referenced-by-count":24,"title":["White Matter Hyperintensities, Exercise, and Improvement in Gait Speed: Does Type of Gait Rehabilitation Matter?"],"prefix":"10.1111","volume":"61","author":[{"given":"Neelesh K.","family":"Nadkarni","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Studenski","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Geriatric Research Education and Clinical Center Veterans Affairs Pittsburgh Healthcare System Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashan","family":"Perera","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Rosano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Brach","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie M.","family":"Van Swearingen","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.6.990"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.12.017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.94"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130530.55104.B5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1419"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr113"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21720"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2280-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2272"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.010"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21826"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6467-9_2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq343"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328304b6a3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.042"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0482"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000111582"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.057"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194256.15247.83"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh186"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1444.017"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822313dc"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp098"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100391"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215502cr515oa"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ptj\/41.2.99","article-title":"Muscle testing. 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