{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:24:58Z","timestamp":1790889898347,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AG09956"],"award-info":[{"award-number":["R01 AG09956"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30 AG10133"],"award-info":[{"award-number":["P30 AG10133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AG019181"],"award-info":[{"award-number":["R01 AG019181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R24 MH080827"],"award-info":[{"award-number":["R24 MH080827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,6]]},"abstract":"\n Objectives<\/jats:title>\n \n To report the results from a prospective cohort study on the association between blood pressure (\n BP<\/jats:styled-content>\n ) and cognitive function in elderly\n A<\/jats:styled-content>\n frican Americans.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective cohort study conducted from 1997 to 2009.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Community\u2010based study in\n I<\/jats:styled-content>\n ndianapolis.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n African Americans aged 65\u00a0years or older (N\u00a0=\u00a03,145).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n At each assessment, participant cognitive function was measured using the\n C<\/jats:styled-content>\n ommunity\n S<\/jats:styled-content>\n creening\n I<\/jats:styled-content>\n nterview for\n D<\/jats:styled-content>\n ementia. Other measurements included\n BP<\/jats:styled-content>\n , height, weight, education level, antihypertensive medication use, alcohol use, smoking, and history of chronic medical conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Longitudinal assessments (n\u00a0=\u00a05,995) contributed by 2,721 participants with complete independent variables were analyzed using a semiparametric mixed\u2010effects model.\n S<\/jats:styled-content>\n ystolic\n BP<\/jats:styled-content>\n (\n SBP<\/jats:styled-content>\n ) of approximately 135\u00a0mmHg and diastolic\n BP<\/jats:styled-content>\n (\n DBP<\/jats:styled-content>\n ) of approximately 80\u00a0mmHg were associated with optimal cognitive function after adjusting for other variables (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n .02). Weight loss with body mass index\u00a0<\u00a030.0\u00a0kg\/m\n 2<\/jats:sup>\n was significantly related to poorer cognitive performance (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n .001). Older age at first assessment, lower education level; smoking; and history of depression, stroke, and diabetes mellitus were related to worse cognitive function; taking antihypertensive medication and drinking alcohol were associated with better cognitive function.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n High and low\n BP<\/jats:styled-content>\n were associated with poorer cognitive performance. A joint optimal region of\n SBP<\/jats:styled-content>\n and\n DBP<\/jats:styled-content>\n for cognitive function has been identified, which may provide useful clinical information on optimal\n BP<\/jats:styled-content>\n control in cognitive health and lead to better quality of life for elderly adults.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12259","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T14:21:50Z","timestamp":1367850110000},"page":"875-881","source":"Crossref","is-referenced-by-count":23,"title":["Optimal Blood Pressure for Cognitive Function: Findings from an Elderly African\u2010American Cohort Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Hai","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biostatistics Indiana University Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department 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