{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:45:15Z","timestamp":1781829915436,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To test the hypothesis that, in older adults, living in a mildly iodine\u2010deficient area, thyroid dysfunction may be associated with mortality independent of potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Community\u2010based.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Nine hundred fifty\u2010one individuals aged 65 and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Plasma thyrotropin, free thyroxine, and free triiodothyronine concentrations and demographic features were evaluated in participants of the Invecchiare in Chianti Study aged 65 and older. Participants were classified according to thyroid function test. Kaplan\u2010Meier survival and Cox proportional hazards models adjusted for confounders were used in the analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight hundred nineteen participants were euthyroid, 83 had subclinical hyperthyroidism (\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      yper), and 29 had subclinical hypothyroidism (\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      ypo). Overt hypo\u2010 and hyperthyroidism were found in five and 15 subjects, respectively. During a median of 6\u00a0years of follow\u2010up, 210 deaths occurred (22.1%), 98 (46.6%) of which were from cardiovascular causes. Kaplan\u2010Meier analysis revealed higher overall mortality for\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      yper (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.04) than euthyroid subjects. After adjusting for multiple confounders, participants with\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      yper (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      )\u00a0=\u00a01.65, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a01.02\u20132.69) had significantly higher all\u2010cause mortality than those with normal thyroid function. No significant association was found between\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      yper and cardiovascular mortality. In euthyroid subjects, thyrotropin was found to be predictive of lower risk of all\u2010cause mortality (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a00.76, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.57\u20130.99).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>\n                      yper is an independent risk factor for all\u2010cause mortality in older adults. Low to normal circulating thyrotropin should be carefully monitored in elderly euthyroid individuals.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12267","type":"journal-article","created":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T14:22:40Z","timestamp":1367850160000},"page":"868-874","source":"Crossref","is-referenced-by-count":55,"title":["Thyroid Status and 6\u2010Year Mortality in Elderly People Living in a Mildly Iodine\u2010Deficient Area: The Aging in the Chianti Area Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Graziano","family":"Ceresini","sequence":"first","affiliation":[{"name":"Department Clinical and Experimental Medicine, Geriatric Endocrine Unit University Hospital of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Ceda","sequence":"additional","affiliation":[{"name":"Department Clinical and Experimental Medicine, Geriatric Endocrine Unit University 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