{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:38:48Z","timestamp":1771033128925,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Foundation of the Italian Society of Diabetology"},{"name":"Diabetes, Endocrinology and Metabolism Foundation"},{"name":"Eli-Lilly Italia"},{"name":"Takeda"},{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Boehringer-Ingelheim"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To assess the distribution of antihyperglycemic treatments according to age and renal function and its relationship with cardiovascular disease in type 2 diabetes mellitus (\n                      <jats:styled-content style=\"fixed-case\">T2DM<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Nineteen hospital\u2010based diabetes mellitus clinics in 2007 and 2008.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Fifteen thousand seven hundred thirty\u2010three individuals with T2DM from the Renal Insufficiency and Cardiovascular Events (\n                      <jats:styled-content style=\"fixed-case\">RIACE<\/jats:styled-content>\n                      ) Italian Multicenter Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Current antihyperglycemic treatments were recorded. Estimated glomerular filtration rate (\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      ) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Albuminuria was measured using immunonephelometry or immunoturbidimetry. Prevalence of major acute cardiovascular events was calculated according to age quartiles, treatments, and categories of\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      (1\u00a0=\u00a0\u226590; 2\u00a0=\u00a060\u201389; 3\u00a0=\u00a030\u201359; and 4\u00a0=\u00a0&lt;30\u00a0mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across age quartiles,\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      declined progressively at a time\u2010linear rate, with an acceleration in older adults, whereas albuminuria increased; age and\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      were associated with cardiovascular events independently of other confounders. With increasing age, percentage of participants using lifestyle treatments for their T2DM and taking metformin or glitazones fell; percentage taking sulphonylureas and repaglinide rose, and percentage taking insulin remained stable. In\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      categories 3 and 4, use of metformin was 41.4% and 14.5%, respectively, and that of sulphonylureas was 34.2% and 18.1%, respectively. Inappropriate prescription of these agents, especially sulphonylureas, increased with age. Metformin was independently associated with lower prevalence of cardiovascular disease for any age quartile and\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      category than all other treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In real\u2010life conditions, use of agents that are not recommended in elderly adults with diabetes mellitus with moderate to severe renal impairment is frequent, but metformin is associated with lower cardiovascular event rates even in these individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12381","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T21:33:08Z","timestamp":1374874388000},"page":"1253-1261","source":"Crossref","is-referenced-by-count":58,"title":["Age, Renal Dysfunction, Cardiovascular Disease, and Antihyperglycemic Treatment in Type 2 Diabetes Mellitus: Findings from the Renal Insufficiency and Cardiovascular Events Italian Multicenter Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Anna","family":"Solini","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Penno","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Bonora","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Fondelli","sequence":"additional","affiliation":[{"name":"Diabetes Unit University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Orsi","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetes Unit Fondazione IRCCS \u201cC\u00e0 Granda\u2010Ospedale Maggiore Policlinico\u201d Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Diabetes Unit A.O. 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