{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:10:28Z","timestamp":1767665428820,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng-Kung University Hospital","doi-asserted-by":"crossref","award":["NCKUHFM-101-003"],"award-info":[{"award-number":["NCKUHFM-101-003"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n Objectives<\/jats:title>\n \n To assess the association between arterial stiffness and mild and moderate chronic kidney disease (\n CKD<\/jats:styled-content>\n ), independent of other cardiometabolic factors in an elderly population.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Health examination data from\n N<\/jats:styled-content>\n ational\n C<\/jats:styled-content>\n heng\n K<\/jats:styled-content>\n ung\n U<\/jats:styled-content>\n niversity\n H<\/jats:styled-content>\n ospital from 2006 to 2009.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Eligible subjects aged 60 and older (N\u00a0=\u00a01,251).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n An average bilateral brachial\u2013ankle pulse wave velocity (ba\n PWV<\/jats:styled-content>\n ) of 1,400\u00a0cm\/s or greater was defined as high ba\n PWV<\/jats:styled-content>\n . Based on the 2003\n C<\/jats:styled-content>\n linical\n P<\/jats:styled-content>\n ractice\n G<\/jats:styled-content>\n uidelines for\n C<\/jats:styled-content>\n hronic\n K<\/jats:styled-content>\n idney\n D<\/jats:styled-content>\n isease from the\n N<\/jats:styled-content>\n ational\n K<\/jats:styled-content>\n idney\n F<\/jats:styled-content>\n oundation, mild and moderate\n CKD<\/jats:styled-content>\n were defined as\n CKD<\/jats:styled-content>\n Stages 1 and 2 and Stages 3 to 5, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants with a ba\n PWV<\/jats:styled-content>\n of 1,400\u00a0cm\/s or greater (n\u00a0=\u00a01,028) had lower estimated glomerular filtration rates (e\n GFR<\/jats:styled-content>\n s) but higher serum creatinine levels and greater prevalences of mild and moderate\n CKD<\/jats:styled-content>\n , diabetes mellitus, prediabetes mellitus, hypertension, and prehypertension than those with ba\n PWV<\/jats:styled-content>\n less than 1,400\u00a0cm\/s (n\u00a0=\u00a0223). In the multivariate analysis, mild (odds ratio (\n OR)<\/jats:styled-content>\n \u00a0=\u00a02.58, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.02\u20136.54) and moderate (\n OR<\/jats:styled-content>\n \u00a0=\u00a03.75, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.02\u201313.81)\n CKD<\/jats:styled-content>\n were positively associated with greater ba\n PWV<\/jats:styled-content>\n (\u22651,400\u00a0cm\/s). Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also independently associated with greater ba\n PWV<\/jats:styled-content>\n . In the multiple linear analysis, moderate (\u03b2\u00a0=\u00a0120.45,\n P<\/jats:italic>\n \u00a0<\u00a0.001) and mild\n CKD<\/jats:styled-content>\n (\u03b2\u00a0=\u00a069.90,\n P<\/jats:italic>\n \u00a0=\u00a0.01) were positively associated with ba\n PWV<\/jats:styled-content>\n . There was also an independently inverse correlation between e\n GFR<\/jats:styled-content>\n and ba\n PWV<\/jats:styled-content>\n (\u03b2\u00a0=\u00a0\u22120.69,\n P<\/jats:italic>\n \u00a0=\u00a0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Mild and moderate\n CKD<\/jats:styled-content>\n increased the risk of greater arterial stiffness in elderly adults. Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also important correlates of increased arterial stiffness.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12445","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T11:23:04Z","timestamp":1380626584000},"page":"1758-1762","source":"Crossref","is-referenced-by-count":9,"title":["Mild Chronic Kidney Disease Associated with Greater Risk of Arterial Stiffness in Elderly Adults"],"prefix":"10.1111","volume":"61","author":[{"given":"I\u2010Ting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Family Medicine National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Shang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Department of Family Medicine College of Medicine 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Family Medicine National Cheng Kung University Hospital Tainan Taiwan"},{"name":"Department of Family Medicine College of Medicine National Cheng Kung University Tainan 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