{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:10:48Z","timestamp":1762189848349,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of Health","award":["ICS 110.1\/RS97.71"],"award-info":[{"award-number":["ICS 110.1\/RS97.71"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["N01-AG-1-2111"],"award-info":[{"award-number":["N01-AG-1-2111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["R24HD047879"],"award-info":[{"award-number":["R24HD047879"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine relationships between eight markers of inflammation (interleukin (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      )\u20106,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106 receptor (R),\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      \u2010reactive protein (\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ), tumor necrosis factor (\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      )\u2010alpha,\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      receptor 1 (R1),\n                      <jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>\n                      2,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20101 receptor antagonist,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u201018) and incident loss of ability to walk 400\u00a0m.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      Older adults enrolled in the\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      nvecchiare in\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      hianti\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Community\u2010dwelling participants aged 65 and older (N\u00a0=\u00a01,006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>The eight inflammatory markers were measured at baseline, and an inflammation score was calculated based on the number of inflammatory markers for which the participant was in the highest quartile. Incidence of mobility disability was determined in participants able to walk 400\u00a0m at baseline. Logistic regression models were used to determine whether each of the inflammatory markers and the inflammation score predicted loss of the ability to walk 400\u00a0m at 6\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjusting for covariates, individuals with a\n                      <jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>\n                      1 level in each of the highest three quartiles (Q2, 3, 4) were more likely to be unable to walk 400\u00a0m at follow\u2010up than those with\n                      <jats:styled-content style=\"fixed-case\">TNFR<\/jats:styled-content>\n                      1 levels in Q1. When adjusting for the same covariates, participants with an inflammation score of 3 or 4 were more likely to become unable to walk 400\u00a0m at follow\u2010up than participants with a score of 0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results provide additional evidence that inflammation is a factor in the mechanisms that cause incident mobility disability and suggest that a combined measure of inflammatory markers may improve prediction of functional prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12446","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T11:22:31Z","timestamp":1380626551000},"page":"1743-1749","source":"Crossref","is-referenced-by-count":13,"title":["Association of Inflammation with Loss of Ability to Walk 400 Meters: Longitudinal Findings from the Invecchiare in Chianti Study"],"prefix":"10.1111","volume":"61","author":[{"given":"Sarinnapha","family":"Vasunilashorn","sequence":"first","affiliation":[{"name":"Office of Population Research Princeton University Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"Longitudinal Studies Section Clinical Research Branch National Institute on Aging Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen M.","family":"Crimmins","sequence":"additional","affiliation":[{"name":"Andrus Gerontology Center University of Southern California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bandinelli","sequence":"additional","affiliation":[{"name":"Geriatric Unit Azienda Sanitaria Firenze Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack 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