{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:03:43Z","timestamp":1785402223239,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,10]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the prevalence of nonmotor symptoms (\n NMS<\/jats:styled-content>\n ) in nursing home (\n NH<\/jats:styled-content>\n ) residents with\n P<\/jats:styled-content>\n arkinson's disease (\n PD<\/jats:styled-content>\n ) and to establish the association with quality of life.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Nursing homes in the southeast of the\n N<\/jats:styled-content>\n etherlands.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Nursing home residents with\n PD<\/jats:styled-content>\n and a\n M<\/jats:styled-content>\n ini\u2010\n M<\/jats:styled-content>\n ental\n S<\/jats:styled-content>\n tate\n E<\/jats:styled-content>\n xamination score of 18 or greater (N\u00a0=\u00a073; mean age 78.7, disease duration 10\u00a0years, mainly\n H<\/jats:styled-content>\n oehn and\n Y<\/jats:styled-content>\n ahr Stages 4 (38%) and 5 (49%)) underwent detailed examination to determine the prevalence of\n NMS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Validated instruments for\n PD<\/jats:styled-content>\n \u2010related\n NMS<\/jats:styled-content>\n were used to examine the\n NH<\/jats:styled-content>\n residents with\n PD<\/jats:styled-content>\n . The overall burden of\n NMS<\/jats:styled-content>\n , and autonomic problems in particular, were measured using the\n N<\/jats:styled-content>\n on\u2010\n M<\/jats:styled-content>\n otor\n S<\/jats:styled-content>\n ymptoms\n S<\/jats:styled-content>\n cale (\n NMSS<\/jats:styled-content>\n ). Depression, neuropsychiatric symptoms, sleep problems, cognitive dysfunction, and motor impairments were focused on in further detail using established clinimetric tests. Linear regression analysis was used to examine the relationship between these symptoms and quality of life, which was measured using the\n P<\/jats:styled-content>\n arkinson's\n D<\/jats:styled-content>\n isease\n Q<\/jats:styled-content>\n uestionnaire (\n PDQ<\/jats:styled-content>\n \u20108).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n NMSS<\/jats:styled-content>\n revealed a mean of nearly 13 different\n NMS<\/jats:styled-content>\n per resident. Autonomic problems (constipation, urinary urgency) were particularly prevalent (48\u201375% of residents). Depressive symptoms were present in 45%. The most prevalent neuropsychiatric symptoms other than depression were irritability and apathy. The most common sleep problems were overall poor nighttime sleep quality, daytime sleepiness, and nocturia. Cognitive problems were highly prevalent, and 77% of the residents met the criteria for\n PD<\/jats:styled-content>\n \u2010related dementia. High scores were also obtained for motor impairments. Mean\n PDQ<\/jats:styled-content>\n \u20108 score was high, indicating poor quality of life. Poor quality of life was most strongly associated with the prevalence and severity of overall\n NMS<\/jats:styled-content>\n burden (coefficient of determination\u00a0=\u00a00.45).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Nonmotor symptoms were highly prevalent in\n NH<\/jats:styled-content>\n residents with\n PD<\/jats:styled-content>\n . Quality of life was poor, largely because of\n NMS<\/jats:styled-content>\n . Because many\n NMS<\/jats:styled-content>\n are potentially treatable, diagnosis and treatment of these severely affected individuals deserve more attention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12458","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:43:43Z","timestamp":1381527823000},"page":"1714-1721","source":"Crossref","is-referenced-by-count":67,"title":["Nonmotor Symptoms in Nursing Home Residents with Parkinson's Disease: Prevalence and Effect on Quality of Life"],"prefix":"10.1111","volume":"61","author":[{"given":"Nico J.","family":"Weerkamp","sequence":"first","affiliation":[{"name":"Department of Neurology Atrium Medical Center Heerlen the Netherlands"},{"name":"Department of Neurology Nijmegen Center for Evidence Based Practice Radboud University Nijmegen Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Tissingh","sequence":"additional","affiliation":[{"name":"Department of Neurology Atrium Medical Center Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra J.E.","family":"Poels","sequence":"additional","affiliation":[{"name":"Department of Neurology Nijmegen Center for Evidence Based Practice Radboud University Nijmegen Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Systse U.","family":"Zuidema","sequence":"additional","affiliation":[{"name":"Department of General Practice University of Groningen University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marten","family":"Munneke","sequence":"additional","affiliation":[{"name":"Department of Neurology Nijmegen Center for Evidence Based Practice Radboud University Nijmegen Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.C.M.","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Department of Primary and Community Care Center for Family Medicine, Geriatric Care and Public Health Radboud University Nijmegen Medical Center Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Department of Neurology Donders Institute for Brain, Cognition and Behavior Radboud University Nijmegen Medical Center Nijmegen the 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