{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:04:40Z","timestamp":1791083080362,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health"},{"name":"L'Association de Recherche SYNAPSE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2013,12]]},"abstract":"\n Objectives<\/jats:title>\n \n To assess the role of the cardiac autonomic nervous system (\n ANS<\/jats:styled-content>\n ), as measured according to spontaneous cardiac baroreflex sensitivity (\n BRS<\/jats:styled-content>\n ), in the type and degree of cognitive performance in healthy young\u2010elderly individuals, taking into account the presence of other vascular risk factors.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Community\u2010based cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n In\u2010home and clinical settings.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n A subset of participants, aged 66.9\u00a0\u00b1\u00a00.9, from a prospective study that aimed to assess the influence of\n ANS<\/jats:styled-content>\n activity on cardiovascular and cerebrovascular morbidity and mortality (N\u00a0=\u00a0916).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n All subjects underwent a clinical interview, neuropsychological testing, and autonomic and vascular measurements. Three cognitive domains were defined: attentional (\n T<\/jats:styled-content>\n rail\u2010\n M<\/jats:styled-content>\n aking\n T<\/jats:styled-content>\n est\n P<\/jats:styled-content>\n art A,\n S<\/jats:styled-content>\n troop code and parts\n I<\/jats:styled-content>\n &\n II<\/jats:styled-content>\n ), executive (\n T<\/jats:styled-content>\n rail\u2010\n M<\/jats:styled-content>\n aking\n T<\/jats:styled-content>\n est\n P<\/jats:styled-content>\n art\n B<\/jats:styled-content>\n , Stroop part\n III<\/jats:styled-content>\n , verbal fluency and similarity tests), and memory (Benton visual retention test, Grober and Buschk\u00e9 procedure). Subjects were stratified according to their scores into normal, low, and impaired performers.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After adjustments to demographic and vascular data, participants with moderate autonomic dysregulation (3\u00a0<\u00a0BRS\u00a0\u2264\u00a06) were determined to be 1.82 times as likely to have memory impairment (odds ratio (\n OR<\/jats:styled-content>\n )\u00a0=\u00a01.82, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.13\u20133.17,\n P<\/jats:italic>\n \u00a0=\u00a0.02) and those with severe autonomic dysregulation (\n BRS<\/jats:styled-content>\n \u00a0\u2264\u00a03) to be 2.65 as likely (\n OR<\/jats:styled-content>\n \u00a0=\u00a02.65, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.40\u20135.59,\n P<\/jats:italic>\n \u00a0=\u00a0.006) as participants with normal\n BRS<\/jats:styled-content>\n (>6).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In older individuals without dementia, autonomic dysregulation seems to have a direct, gradual, and independent effect on memory. Future studies are needed to evaluate the long\u2010term effects of\n BRS<\/jats:styled-content>\n and other markers of the\n ANS<\/jats:styled-content>\n on cognitive decline.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12548","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T11:05:48Z","timestamp":1385463948000},"page":"2096-2102","source":"Crossref","is-referenced-by-count":32,"title":["Baroreflex Sensitivity, Vascular Risk Factors, and Cognitive Function in a Healthy Elderly Population: The\n PROOF<\/scp>\n Cohort"],"prefix":"10.1111","volume":"61","author":[{"given":"Magali","family":"Saint Martin","sequence":"first","affiliation":[{"name":"D\u00e9partement de Physiologie Clinique et de l'Exercice P\u00f4le Neuro\u2010Ost\u00e9oLocomoteur Centre Hospitalo\u2010Universitaire Saint\u2010\u00c9tienne France"},{"name":"Facult\u00e9 de M\u00e9dicine de Saint\u2010Etienne Universit\u00e9 Jean Moulin Saint\u2010\u00c9tienne 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France"},{"name":"P\u00f4le de Recherche et d'Enseignement Sup\u00e9rieur Universit\u00e9 de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The PROOF Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.10.039"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6944.1604"},{"key":"e_1_2_6_4_1","first-page":"340","article-title":"Cardiovascular risk factors as potential markers for mild cognitive impairment and Alzheimer's disease","volume":"23","author":"Ciobica A","year":"2011","journal-title":"Psychiatr Danub"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.10.032"},{"key":"e_1_2_6_6_1","first-page":"42","article-title":"Carotid intimal medial thickness predicts cognitive 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