{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:40:06Z","timestamp":1790617206448,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the cognitive profile of a population representative sample with orthostatic hypotension (OH) with the profile of a sample without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis of a prospective nationally representative population study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      The Irish Longitudinal Study on Ageing (\n                      <jats:styled-content style=\"fixed-case\">TILDA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">TILDA<\/jats:styled-content>\n                      participants (N\u00a0=\u00a05,936; mean age 63\u00a0\u00b1\u00a09, 54% female).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      was defined as a drop of 20\u00a0mmHg or more in systolic blood pressure or of 10\u00a0mmHg or more in diastolic blood pressure on standing from a seated position. Cognitive performance was assessed using comprehensive cognitive tests measuring domains of global function, executive function, processing speed, attention, and memory, from which composite standardized scores were computed. Multivariate analysis controlling for potential confounders was performed to compare cognitive performance according to\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Prevalence of\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      was 6.1% (95% confidence interval\u00a0=\u00a05.4\u20136.7%). A significant negative association between\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      status and global cognitive function (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.21,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0.01) and memory (\n                      <jats:italic>\u03b2\u00a0<\/jats:italic>\n                      =\u00a0\u22120.26,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) was found in women aged 65 and older after adjustment for demographic characteristics, mental health, cardiovascular disease, and medications (antihypertensive and antipsychotic), but other specific cognitive domains were not affected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      was associated with poorer global cognitive function and poorer memory, independent of potential confounders, in women in a large population\u2010based sample of older adults. Longitudinal studies with concomitant assessment of cerebral perfusion are needed to determine causal relationships.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.12592","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T09:25:46Z","timestamp":1389950746000},"page":"117-122","source":"Crossref","is-referenced-by-count":52,"title":["Cognitive Performance in Orthostatic Hypotension: Findings from a Nationally Representative Sample"],"prefix":"10.1111","volume":"62","author":[{"given":"John","family":"Frewen","sequence":"first","affiliation":[{"name":"Irish Longitudinal Study on Ageing Trinity College Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Savva","sequence":"additional","affiliation":[{"name":"Irish Longitudinal Study on Ageing Trinity College Dublin Ireland"},{"name":"School of Nursing Sciences University of East Anglia Norwich Norfolk 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