{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:53:08Z","timestamp":1774961588701,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45580"],"award-info":[{"award-number":["U01 AR45580"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45614"],"award-info":[{"award-number":["U01 AR45614"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45632"],"award-info":[{"award-number":["U01 AR45632"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45647"],"award-info":[{"award-number":["U01 AR45647"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45654"],"award-info":[{"award-number":["U01 AR45654"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR45583"],"award-info":[{"award-number":["U01 AR45583"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01AG18197"],"award-info":[{"award-number":["U01AG18197"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01-AG027810"],"award-info":[{"award-number":["U01-AG027810"]}]},{"name":"NIH Roadmap for Medical Research","award":["UL1 RR024140"],"award-info":[{"award-number":["UL1 RR024140"]}]},{"name":"Claude D. Pepper Older Americans Independence Center"},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MrOS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,1]]},"abstract":"\n Objectives<\/jats:title>\n \n To study the association between blood lead concentration (\n BP<\/jats:styled-content>\n b) and bone mineral density (\n BMD<\/jats:styled-content>\n ), physical function, and cognitive function in noninstitutionalized community\u2010dwelling older men.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n U<\/jats:styled-content>\n niversity of\n P<\/jats:styled-content>\n ittsburgh clinic,\n P<\/jats:styled-content>\n ittsburgh,\n P<\/jats:styled-content>\n ennsylvania.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n N<\/jats:styled-content>\n on\u2010\n H<\/jats:styled-content>\n ispanic\n C<\/jats:styled-content>\n aucasian men aged 65 and older (N\u00a0=\u00a0445) recruited as a subset of a prospective cohort for the\n O<\/jats:styled-content>\n steoporotic\n F<\/jats:styled-content>\n ractures in\n M<\/jats:styled-content>\n en\n S<\/jats:styled-content>\n tudy.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n BP<\/jats:styled-content>\n b was measured in 2007\/08. From 2007 to 2009,\n BMD<\/jats:styled-content>\n (g\/cm\n 2<\/jats:sup>\n ) was measured using dual\u2010energy X\u2010ray absorptiometry. At the same time, physical performance was measured using five tests: grip strength, leg extension power, walking speed, narrow\u2010walk pace, and chair stands. Cognitive performance was assessed using the modified\n M<\/jats:styled-content>\n ini\u2010\n M<\/jats:styled-content>\n ental\n S<\/jats:styled-content>\n tate\n E<\/jats:styled-content>\n xamination and the\n T<\/jats:styled-content>\n rail\u2010\n M<\/jats:styled-content>\n aking\n T<\/jats:styled-content>\n est\n P<\/jats:styled-content>\n art\n B<\/jats:styled-content>\n . Participants were categorized into quartiles of\n BP<\/jats:styled-content>\n b. Multivariate regression analysis was used to evaluate the independent relationship between\n BP<\/jats:styled-content>\n b,\n BMD<\/jats:styled-content>\n , and cognitive and physical function.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean\n BP<\/jats:styled-content>\n b\u00a0\u00b1\u00a0standard deviation was 2.25\u00a0\u00b1\u00a01.20\u00a0\u03bcg\/dL (median 2\u00a0\u03bcg\/dL, range 1\u201310\u00a0\u03bcg\/dL). In multivariate\u2010adjusted models, men in higher\n BP<\/jats:styled-content>\n b quartiles had lower\n BMD<\/jats:styled-content>\n at femoral neck and total hip (\n P<\/jats:italic>\n \u2010trend\u00a0<\u00a0.001 for both). Men with higher\n BP<\/jats:styled-content>\n b had lower age\u2010adjusted score for grip strength (\n P<\/jats:italic>\n \u2010trend\u00a0<\u00a0.001), although this association was not significant in multivariate\u2010adjusted models (\n P<\/jats:italic>\n \u2010trend\u00a0<\u00a0.15).\n BP<\/jats:styled-content>\n b was not associated with lumbar spine\n BMD<\/jats:styled-content>\n , cognition, leg extension power, walking speed, narrow\u2010walk pace, or chair stands.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Environmental lead exposure may adversely affect bone health in older men. These findings support consideration of environmental exposure in age\u2010associated bone fragility.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12603","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T13:21:08Z","timestamp":1388668868000},"page":"141-146","source":"Crossref","is-referenced-by-count":21,"title":["Associations Between Bone Mineral Density, Grip Strength, and Lead Body Burden in Older Men"],"prefix":"10.1111","volume":"62","author":[{"given":"Naila","family":"Khalil","sequence":"first","affiliation":[{"name":"Center for Global Health Department of Community Health Boonshoft School of Medicine Wright State University Dayton Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Greenspan","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine Department of Medicine Medical School University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Osteoporotic Fractures in Men Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.04.018"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-1045-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090706"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh296"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080404"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205918"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2013.01.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.52.6.415"},{"key":"e_1_2_6_13_1","unstructured":"U.S. Department of Health and Human Services Centers for Disease Control and Prevention.Fourth Report on Human Exposure to Environmental Chemicals Updated Tables September 2013.Atlanta GA:U.S. Department of Health and Human Services Centers for Disease Control and Prevention[on\u2010line]. Available athttp:\/\/www.cdc.gov\/exposurereportAccessed October 28 2013."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.919117"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2005.05.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0584-8547(93)80094-B"},{"key":"e_1_2_6_17_1","volume-title":"Fourth Report on Human Exposure to Environmental Chemicals","author":"Centers for Disease Control and Prevention (CDC)"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.86"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050143"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90878-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080227"},{"key":"e_1_2_6_22_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) examination","volume":"48","author":"Teng EL","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.2000.48.11.1501"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9716"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1866-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8106"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.12603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.12603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.12603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:30:24Z","timestamp":1762191024000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.12603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/jgs.12603"],"URL":"https:\/\/doi.org\/10.1111\/jgs.12603","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}