{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:51Z","timestamp":1791252831772,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Objectives<\/jats:title>\n \n To quantify the effect of nosocomial bloodstream infection (\n BSI<\/jats:styled-content>\n ) on older adults, including mortality, length of stay (\n LOS<\/jats:styled-content>\n ), and costs attributed to\n BSI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Eight acute care hospitals (7 community hospitals and 1 tertiary university\u2010affiliated facility) belonging to the Duke Infection Control Outreach Network (DICON) from the states of North Carolina and Virginia.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Elderly patients over 65 years of age.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n A multistate, multicenter, matched, retrospective cohort study was conducted from January 1994 through June 2002 in eight hospitals from the Southern\u2010Central United States. Patients aged >65\u00a0years with nosocomial\n BSI<\/jats:styled-content>\n were enrolled. Controls without bloodstream infection were matched to cases. Outcomes during the 90\u2010day period following hospital discharge were evaluated to determine the association between\n BSI<\/jats:styled-content>\n and mortality, hospital costs, and\n LOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eight\u2010hundred thirty cases and 830 matched controls were identified, all with a mean age of 74.4\u00a0years. Among cases, 81% of\n BSI<\/jats:styled-content>\n s were central line\u2010associated and\n Staphylococcus aureus<\/jats:italic>\n was the most common pathogen accounting for 34.6% of infections (2\/3 were methicillin resistant). The mortality rate of cases was 49.4%, compared to 33.2% for controls (\n OR<\/jats:styled-content>\n \u00a0=\u00a02.1,\n P<\/jats:italic>\n \u00a0<\u00a0.001),\n LOS<\/jats:styled-content>\n was 29.2\u00a0days for cases and 20.2\u00a0days for controls (\n P<\/jats:italic>\n \u00a0<\u00a0.001), and hospital charges were $102,276 for cases compared to $69,690 for controls (\n P<\/jats:italic>\n \u00a0<\u00a0.001). The mean\n LOS<\/jats:styled-content>\n and mean costs attributable to\n BSI<\/jats:styled-content>\n were 10\u00a0days and $43,208, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Nosocomial\n BSI<\/jats:styled-content>\n in older adults was significantly associated with increases in 90\u2010day mortality, increased\n LOS<\/jats:styled-content>\n , and increased costs of care. Preventive interventions to eliminate nosocomial\n BSI<\/jats:styled-content>\n s in older adults would likely be cost effective.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12634","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T12:31:53Z","timestamp":1389961913000},"page":"306-311","source":"Crossref","is-referenced-by-count":130,"title":["Effect of Nosocomial Bloodstream Infections on Mortality, Length of Stay, and Hospital Costs in Older Adults"],"prefix":"10.1111","volume":"62","author":[{"given":"Keith S.","family":"Kaye","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Detroit Medical Center Wayne State University Detroit Michigan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Marchaim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Detroit Medical Center Wayne State University Detroit Michigan Israel"},{"name":"Division of Infectious Diseases Assaf Harofeh Medical Center Zerifin Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Detroit Medical Center Wayne State University Detroit Michigan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Baures","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Detroit Medical Center Wayne State University Detroit Michigan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deverick J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Infection Control Outreach Network Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Infection Control Outreach Network Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sloane","sequence":"additional","affiliation":[{"name":"Center for the Study of Aging and Human Development Duke Infection Control Outreach Network Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E","family":"Schmader","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke Infection Control Outreach Network Durham North Carolina"},{"name":"Division of Geriatrics Duke Infection Control Outreach Network Durham North Carolina"},{"name":"Geriatric Research Education and Clinical Center Veterans Affairs Medical Center Durham North 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