{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:28:24Z","timestamp":1789450104686,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006528","name":"ADRC","doi-asserted-by":"crossref","award":["K23-AG-032872"],"award-info":[{"award-number":["K23-AG-032872"]}],"id":[{"id":"10.13039\/100006528","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006528","name":"ADRC","doi-asserted-by":"crossref","award":["K23-AG-032872"],"award-info":[{"award-number":["K23-AG-032872"]}],"id":[{"id":"10.13039\/100006528","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006528","name":"ADRC","doi-asserted-by":"crossref","award":["P50 AG023501"],"award-info":[{"award-number":["P50 AG023501"]}],"id":[{"id":"10.13039\/100006528","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UCSF CFAR","award":["P30-AI027763"],"award-info":[{"award-number":["P30-AI027763"]}]},{"name":"UCSF GCRC","award":["UL1 RR024131"],"award-info":[{"award-number":["UL1 RR024131"]}]},{"DOI":"10.13039\/100001167","name":"the Larry L. 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Common comorbidities included hyperlipidemia, hypertension, and depression. Participants were taking a median of 13 medications (range 2\u201338), of which only a median of four were antiretrovirals. At least one\n PIM<\/jats:styled-content>\n was prescribed in 46 participants (52%). Sixty\u2010two (70%) participants had at least one\n C<\/jats:styled-content>\n ategory\n D<\/jats:styled-content>\n (consider therapy modification) drug\u2013drug interaction, and 10 (11%) had a Category\n X<\/jats:styled-content>\n (avoid combination) interaction. One\u2010third of these interactions were between two nonantiretroviral medications. Fifteen participants (17%) had an\n ARS<\/jats:styled-content>\n score of 3 or greater. In contrast, HIV\u2010negative participants were taking a median of six medications, 29% had at least one\n PIM<\/jats:styled-content>\n , and 4% had an\n ARS<\/jats:styled-content>\n score of 3 or greater (\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u00a0<\u00a0.05 for each comparison, except\n \n P<\/jats:styled-content>\n <\/jats:italic>\n \u00a0=\u00a0.07 for anticholinergic burden).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n HIV\u2010positive older adults have a high frequency of medication\u2010related problems, of which a large portion is due to medications used to treat comorbid diseases. These medication issues were substantially higher than HIV\u2010negative participants. Attention to the principles of geriatric prescribing is needed as this population ages in order to minimize complications from multiple medication use.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12695","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T14:17:09Z","timestamp":1393510629000},"page":"447-453","source":"Crossref","is-referenced-by-count":144,"title":["Polypharmacy, Drug\u2013Drug Interactions, and Potentially Inappropriate Medications in Older Adults with Human Immunodeficiency Virus Infection"],"prefix":"10.1111","volume":"62","author":[{"given":"Meredith","family":"Greene","sequence":"first","affiliation":[{"name":"Division of Geriatrics Department of Medicine University of California, San Francisco San Francisco California"},{"name":"San Francisco Veterans Affairs Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Steinman","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Medicine University of California, San Francisco San Francisco California"},{"name":"San Francisco Veterans Affairs Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"McNicholl","sequence":"additional","affiliation":[{"name":"Positive Health Program San Francisco General Hospital University of California, San Francisco San Francisco California"},{"name":"School of Pharmacy University of California, San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Valcour","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Medicine University of California, San Francisco San Francisco California"},{"name":"Memory and Aging Center Department of Neurology University of California, San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03948.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.3728"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1326"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-010-0006-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000134665.58343.8D"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181945eb0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054910"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31826bfc53"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1482"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2076"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2004.18.568"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1540"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr248"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.5.480"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03795.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0105-Rev"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2007.12.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49042.x"},{"key":"e_1_2_6_21_1","volume-title":"Lexicomp Lexi\u2010Interact Online","author":"Lexi\u2010Comp, Inc.","year":"2013"},{"key":"e_1_2_6_22_1","unstructured":"Micromedex 2.0. 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